CYTOCON DB

Cell and cYTOkine CONcentrations Database

CYTOCON DB is a manually curated online database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.

CYTOCON DB is designed for Quantitative Systems Pharmacology (QSP) modelers and scientists who deal with biomarker analysis to simplify their hard work and avoid potential errors. Information collected in the database enables them to save time typically spent for gathering and processing of literature and available data utilized for:

comparative analysis of mean values and ranges of baseline cytokine and cell concentrations measured in various tissues of patients suffering from different diseases
calibration of a QSP model of a reference virtual patient (VP) against mean values of cell and cytokines concentrations
selection of plausible VP population against ranges of cell and cytokines concentrations

More info about CYTOCON DB and examples of its application in data analysis and QSP projects can be found in our paper

CYTOCON: The manually curated database of human in vivo cell and molecule concentrations CPT Pharmacometrics Syst Pharmacol. 2022 Sep 21. doi: 10.1002/psp4.12867

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Key features of CYTOCON DB:

Search for a cell/cytokine concentration in a selected disease, tissue (or a group of diseases and tissues), patient group
Unification of measurement units: conversion of source original units to "pM" for cytokine and "kcell/L" for a cell concentration
Table representation of search results: average value and dispersion of a cell/cytokine concentration in original and unified units, tissue type, data source, patient group and disease attributes are specified
Graphic representation of search results: average value, dispersion
Export of search results in CSV format

Search query for a cell concentration can include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
Search query can include following patient group attributes:

demographic characteristics (age, race, gender, etc)
number of patients in study

Search query can take into account disease-specific clinically measured characteristics, for example:

Asthma: FEV1
SLE: SLEADAI range, interferon signature
Atopic Dermatitis: SCORAD range, severity, range of IgE concentration, etc

Content of CYTOCON DB:

355 disease
types

210 tissues/
physiological
fluids

519
molecules

172 cell types
and states

52169 values
of cytokine/cell
concentrations

data extracted
from 1420
papers/other
public sources

Both content and functionality of CYTOCON DB are updated on a monthly basis (approximately 1500 cell/molecule concentrations per month)

CYTOCON DB is accessible via purchasing the commercial license. To purchase the license or ask questions, please contact us by email: support@insysbio.com

CYTOCON DB Open

Cell and cYTOkine CONcentrations Database Open

CYTOCON DB Open is a reduced public version of CYTOCON DB designed to experience the database for free. CYTOCON DB Open differs from CYTOCON DB in content and functional features. Functionality of CYTOCON DB Open are updated once per year.

Access to CYTOCON DB Open

To start working with CYTOCON DB Open, please register an account:

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Content of CYTOCON DB Open:

280 disease
types

183 tissues/
physiological
fluids

452
molecules

156 cell types
and states

34967 values
of cytokine/cell
concentrations

data extracted
from 991
papers/other
public sources