About CYTOCON

CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.

CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.

CYTOCON team makes an effort in two directions: the collection and processing of appropriate data on human immune cell and cytokine concentrations available in public domain (content of CYTOCON DB) and the development of tools/methods for processing, extraction and visualization of the data (CYTOCON DB).

Key features of CYTOCON DB:

Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
Search query may include following patient group attributes:
- demographic characteristics (age, race, gender, etc);
- number of patients in the study.
Search query may take into account disease-specific clinically measured characteristics, for example:
- Asthma: FEV1;
- SLE: SLEADAI range, interferon signature;
- Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
- etc.
Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
Graphic representation of search results: average value, dispersion, source.
Export of search results in csv format

Content of CYTOCON DB:

355 disease types, press to view details;
- Acinic cell adenocarcinoma
- Acute allergic reactions
- Acute coronary syndrome
- Acute coronary syndrome, nonocclusive type (unstable angina)
- Acute coronary syndrome, occlusive type (transmural myocardial infarction)
- Acute disseminated encephalomyelitis (ADEM)
- Acute hepatitis B
- Acute lymphoblastic leukemia
- Acute lymphoid leukaemia
- Acute myeloid leukaemia
- Acute pancreatitis
- Acute pyelonephritis
- Acute-on-chronic liver failure
- Adenocarcinoma of bronchus or lung
- Adenocarcinoma of cervix
- Adenocarcinoma of oesophagus
- Adenocarcinoma of stomach
- Adenoid cystic carcinoma
- Adenosquamous carcinoma of bronchus or lung
- Adult T-cell leukaemia/lymphoma (ATLL)
- adult-onset Still’s disease (AOSD)
- AIDS
- AIDS-related non-Hodgkin lymphoma
- Alcohol-induced dementia
- Allergic asthma
- Allergic contact dermatitis
- Allergic rhinitis
- Alveolar rhabdomyosarcoma
- Alveolar soft part sarcoma
- Alzheimer disease
- Aneurysmal Subarachnoid Hemorrhage
- Angiosarcoma
- Ankylosing spondylitis
- Aplastic anemia
- Appendicitis and Diverticulitis
- Asthma
- Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)
- Asymptomatic HBV carriers
- Atopic allergy
- Atopic asthma
- Atopic dermatitis
- Atopy, nonasthma
- Atrial fibrillation
- Atypical autism (F84.1)
- Atypical hyperplasia
- Autism (F84.0)
- Autism spectrum disorder
- Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy
- Bacterial pneumonia
- Basal cell carcinoma
- B-cell non-Hodgkin lymphoma (B-NHL)
- B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
- Behçet's disease
- Benign conditions of ovary and uterus
- Benign lung lesions
- Benign ovarian pathologies
- Benign reactive lymphoid hyperplasia
- Benign soft-tissue neoplasm
- Bladder cancer
- Brain trauma
- Breast cancer
- Breast carcinoma
- Breast ductal carcinoma
- Bronchial asthma
- Bronchiectasis
- Bronchioalveolar adenocarcinoma
- Bronchoalveolar carcinoma
- Bullous pemphigoid
- Carcinoma
- CD40L deficiency
- Celiac disease
- Central nervous system infection
- Cerebrovascular disease no-dementia
- Cervical cancer
- Cervical carcinoma
- Cervical intraepithelial neoplasia
- Chest infections
- Chondrosarcoma
- Chordoma
- Chronic atrophic gastritis
- Chronic Bronchial Asthma
- Chronic bronchitis (COPD)
- Chronic calculous cholecystitis
- Chronic cholecystitis
- Chronic cough
- Chronic hepatitis
- Chronic hepatitis B
- Chronic Hepatitis C
- Chronic idiopathic urticaria, hives
- Chronic kidney disease
- Chronic liver failure (CLF)
- Chronic myelogenous leukemia
- Chronic myeloid leukaemia
- Chronic obstructive pulmonary disease (COPD)
- Chronic Spontaneous Urticaria
- Chronic superficial gastritis
- Clear cell sarcoma
- Coeliac disease
- Colitis
- Colitis associated cancer (CAC)
- Collagenous colitis
- Colon adenocarcinoma
- Colon carcinoma
- Colonic cancer
- Colorectal cancer (CRC)
- Colorectal polyp
- Common variable immunodeficiency (CVID)
- Community acquired pneumonia
- Contact dermatitis
- COVID-19
- COVID-19 pneumonia
- Crohn's disease
- Cutaneous Lupus Erythematosus
- Cutaneous squamous cell carcinoma
- Cutaneous T-cell lymphoma
- Cyclic neutropenia
- Cystic fibrosis
- Dedifferentiated liposarcoma
- Deep vein thrombosis
- Dementia with Lewy bodies (DLB)
- Dengue
- Depression (6A70.Z Single episode depressive disorder)
- Dermatomyositis
- Dermatophytosis
- Desmoplastic small round cell tumour
- DFSP dermatofibrosarcoma protuberans
- Discoid Lupus Erythematosus
- Dysbacteriosis
- Dysmyelopoiesis
- Early arthritis
- Embryonal rhabdomyosarcoma
- End stage renal disease
- Endometrial carcinoma
- Endometriosis
- Enthesitis-related arthritis
- Eosinophilia
- Eosinophilic asthma
- Eosinophilic bronchitis
- Epithelioid sarcoma
- Epstein-Barr virus (EBV) infection
- Erythema multiforme
- Esophageal cancer
- Esophageal carcinoma
- Ewing sarcoma
- Familial lecithin:cholesterol acyltransferase (LCAT) deficiency
- Familial lipoprotein lipase (LPL) deficiency
- Fanconi anaemia
- Fibrotic hypersensitivity pneumonitis
- Focal segmental glomerulosclerosis
- Follicular lymphoma
- Frontotemporal lobe dementia (FTLD)
- Gallbladder cancer
- Gallbladder dysplasia
- Gastric adenocarcinoma
- Gastric cancer
- Gastric ulcer
- GIST gastrointestinal stromal tumour
- Gliosarcoma
- Gout
- HBV carriers
- HBV-related cirrhosis
- HBV-related HCC (hepatocellular carcinoma)
- Head and neck cancer
- Head and Neck Squamous Cell Carcinoma
- Healthy control
- Hepatitis B
- Hepatitis non-infectious
- Hepatocellular carcinoma (HCC)
- HIV infection
- Hodgkin's lymphoma
- Human immunodeficiency virus (HIV-1) infection
- Hypopharyngeal squamous cell carcinoma
- Idiopathic aplastic anemia
- Idiopathic inflammatory myopathies
- Idiopathic interstitial pneumonia
- Idiopathic pulmonary fibrosis
- IgA glomerulonephriris
- IgA-deficiency disorder
- Immune thrombocytopenia
- Immunoglobulin (Ig)G subclass-deficiency
- Immunoglobulin A nephropathy (IgAN)
- Infection of high-risk human papillomavirus (HPV)
- Infections
- Infectious colitis
- Inflammatory Bowel Diseases
- Inflammatory breast cancer (IBC)
- Influenza
- Interstitial pneumonia with autoimmune features
- Irritable Bowel Syndrome
- Ischemic stroke
- Juvenile chronic arthritis
- Juvenile idiopathic arthritis
- Kawasaki disease
- Langerhans cell histiocytosis
- Large cell carcinoma of bronchus or lung
- Laryngeal papilloma
- Laryngeal Squamous Cell Carcinoma
- Leiomyosarcoma
- Liver cirrhosis
- Liver hemangioma
- Low-grade fibromyxoid sarcoma
- Lung cancer
- Lupus nephritis
- Lymphadenopathic mastocytosis with eosinophilia
- Lymphocytic colitis
- Macrophage activation syndrome
- Major depressive disorder
- Malignant melanoma
- Malignant salivary gland tumors
- Melanoma
- Membranous nephropathy
- Metaplastic breast carcinoma
- Microcrystal arthritis
- Mild cognitive impairment (MCI)
- Mild cognitive impairment with Alzheimer’s disease (MCI-AD)
- Mild cognitive impairment with Lewy body dementia (MCI-LB)
- Minimal change disease (MCD, minimal change glomerulopathy)
- Mixed germ cell tumor
- Mixed granulocytic asthma
- Monoclonal gammopathy of undetermined significance (MGUS)
- Morbidly obese
- MPNST malignant peripheral nerve sheath tumor
- Mucoepidermoid carcinoma
- Multiple myeloma
- Multiple sclerosis
- Multisystem inflammatory syndrome associated with COVID-19
- Myasthenia gravis
- Myelodysplastic syndrome
- Myelomonocytic leukemia
- Myoma
- Myxofibrosarcoma
- Myxoid/round cell liposarcoma (MRCL)
- Nasopharyngeal squamous cell carcinoma
- Neuroblastoma
- Neutrophilic asthma
- Nocturnal Asthma
- Non-atopic asthma
- Nonautoimmune diseases
- Non-eosinophilic asthma
- Non-fibrotic lung diseases
- Non-Hodgkin Lymphoma
- Non-Hodgkin's lymphoma and Hodgkin's lymhoma patients
- Non-idiopathic pulmonary fibrosis
- Non-infected ICU patients
- Non-infection emergency department patients
- Non-inflammatory neurological diseases (NIND)
- Non-psoriatic arthritis spondyloarthritis (non-PsA SpA)
- Non-Small Cell Lung Cancer (NSCLC)
- Non-squamous bronchial carcinoma
- Non-translocation sarcoma
- Novel coronavirus pneumonia
- Nummular Eczema
- Obesity
- Oral cavity squamous cell carcinoma
- Oral leukoplakia
- Oral lichen planus
- Oral squamous cell carcinoma
- Oral submucous fibrosis
- Oropharyngeal squamous cell carcinoma
- Osteoarthritis
- Osteoarthritis inflammatory
- Osteosarcoma
- Other inflammatory neurological disorders
- Ovarian cancer
- Ovarian clear cell carcinoma
- Pancreatic cancer
- Pancreatic ductal adenocarcinoma
- Parotid gland acinic cell carcinoma
- Parotid gland myoepithelioma
- Parotid gland pleomorphic adenoma
- Parotid gland Warthin’s tumor
- Paucigranulocytic asthma
- Pemphigus vulgaris
- Pleomorphic adenoma
- Pneumonia
- Polycystic ovarian syndrome
- Polycythaemia vera
- Primary angle closure glaucoma
- Primary bronchial carcinoma
- Primitive neuroectodermal tumor
- Progressive supranuclear palsy (PSP)
- Prostate cancer
- Psoriasis
- Psoriatic arthritis
- Pulmonary embolism
- Pulmonary emphysema
- Reactive arthritis
- Recurrent depressive disorders
- Refractory Bone and Soft Tissue Sarcoma
- Relapsing polychondritis
- Renal carcinoma
- Renal cell carcinoma
- Renal dysfunction
- Respiratory syncytial virus (RSV) pneumonia
- Rheumatoid arthritis
- Sarcoidosis
- Sarcoma
- SARS-CoV-2 pneumonia
- Schizophrenia
- Sclerodermia
- Sclerosing lymphocytic lobulitis of the breast
- Seborrheic dermatitis
- Sepsis
- Septic shock
- Sjogrens syndrome
- Skin cancer
- Small bowel Crohn's disease
- Small cell carcinoma of bronchus or lung
- Small cell lung cancer (SCLC)
- Soft tissue sarcoma
- Solid malignant tumors
- Solitary fibrous tumor
- Spondyloarthritis
- Spondyloarthropathy
- Sporadic colorectal cancer (SCRC)
- Squamous cell carcinoma of bronchus or lung
- Squamous cell carcinoma of cervix
- Squamous cell carcinoma of oesophagus
- Squamous cell lung cancer
- Stable angina
- Stable coronary artery disease (SCAD)
- Stat3-Hyper-IgE syndrome
- Stress-induced (Takotsubo) cardiomyopathy
- Symptomatic cartilage defects
- Synovial sarcoma
- System indolent mastocytosis
- Systemic lupus erythematosus
- Systemic onset juvenile idiopathic arthritis
- T-cell acute lymphoid leukemia
- T-cell non-Hodgkin lymphoma
- Thrombocytopenia
- Thrombocytosis
- Thyroid adenoma
- Thyroid cancer
- Thyroid carcinoma
- Translocation-associated sarcoma
- Traumatic ulcers
- Tuberculosis
- Type 1 diabetes
- Type 2 diabetes
- Ulcerative colitis
- Undifferentiated arthritis
- Unexplained recurrent anaphylaxis
- Upper gastrointestinal cancers
- UPS undifferentiated pleomorphic sarcoma
- Urinary tract infection
- Urticaria pigmentosa
- Uterine cervical cancer
- Uveal melanoma
- Vascular dementia
- Viral meningoencephalitis
- Wegener’s granuloma
- Well-differentiated liposarcoma
- X-linked agammaglobulinaemia
- X-linked severe combined immunodeficiency (SCID-X1)
210 tissues/physiological fluids, press to view details;
- Adenocarcinoma of oesophagus tumor tissue
- Airway (bronchial) epithelium
- Airway lamina propria
- Airway smooth muscle
- Airways adventitia
- Airways basement membrane
- Ascending colon lamina propria
- Basement membrane of epidermis
- Basement membrane of epidermis lesional
- Basement membrane of epidermis nonlesional
- Benign lung lesion homogenates
- Blood
- Blood arterial
- Blood from tumor
- Bone marrow
- Bone marrow blood
- Bone marrow plasma
- Brain tissue lysate (BA21)
- Breast cancer invasive margin
- Breast cancer tumor center
- Breast cancer tumor tissue
- Breast intra-ductal region
- Breast intra-lobular region
- Breast parenchyma
- Breast peri-ductal region
- Breast peri-lobular region
- Breast peri-vascular region
- Bronchial glands
- Bronchial mucosa
- Bronchial subepithelial tissue
- Bronchial submucosa
- Bronchial tissue
- Bronchial wash
- Bronchoalveolar carcinoma tumor tissue
- Broncho-alveolar lavage (BAL)
- Caecum lamina propria
- Caecum lymphoid aggregates
- Caecum mucosa
- Cartilage
- Cerebrospinal fluid (CSF)
- Cervical tissue
- Cervical tumor tissue
- Cervix squamous cell carcinoma tumor tissue
- Colon
- Colon epithelium
- colon lamina propria lymphoid aggregates/solitary follicles
- colon lamina propria outside lymphoid aggregates/solitary follicles
- Colon mucosa
- Colonic lamina propria
- Colonic lymphoid follicles
- Colorectal cancer tumor center
- Colorectal cancer tumor invasive margin
- Colorectal cancer tumor tissue
- Coproextracts
- Dermis
- Dermis papillary
- Dermis papillary lesional
- Dermis papillary nonlesional
- Dermis upper
- Dermis upper lesional
- Dermis upper nonlesional
- Descending colon mucosa
- Distant metastasis
- Duodenal lamina propria
- Duodenal mucosa
- Endobronchial (airway) biopsies
- Epidermis
- Epithelial lining fluid in airways
- Esophageal cancer tumor tissue
- Esophageal tumor tissue lysate
- Exhaled Breath Condensate
- Gastric mucosa
- Gastric polyp tissue
- Gastric tissue
- Gastric tumor tissue
- Gastritis tissue
- Gut-associated lymphoid tissue
- HCC peritumoral stroma
- HCC peritumoral tissue
- Head and Neck Squamous Cell Carcinoma primary tumor
- Hepatocellular carcinoma tumor tissue
- Ileal mucosa
- Ileal mucosa inflamed
- Ileal mucosa non-inflamed
- Ileum epithelium
- Ileum lamina propria
- Ileum lymphoid aggregates
- Ileum/Colon mucosa
- Induced Sputum
- Inflamed caecum mucosa
- Inflamed colon mucosa
- Inflamed colonic lamina propria
- Inflamed descending colon mucosa
- Inflamed ileum lamina propria
- Inflamed intestinal lamina propria
- Inflamed left flexure mucosa
- Inflamed rectum mucosa
- Inflamed right flexure mucosa
- Inflamed sigmoid colon mucosa
- Intermediate lymph node
- Intestinal adventitia
- Intestinal granulomas
- Intestinal lamina propria
- Intestinal lymphoid aggregates
- Intestinal mucosa
- Intestinal mucosa lymphoid follicules
- Intestinal muscular
- Intestinal submucosa
- Intratumor soft tissue of synovial sarcoma
- Intratumoral region of tumor-draining/sentinel lymph node - metastatic
- Invasive margin of tumor soft tissue of synovial sarcoma
- Jejunal epithelium
- Jejunal lamina propria
- Left flexure mucosa
- Lesional dermis
- Lesional epidermis
- Lesional skin
- Liver
- Liver metastases peritumoral
- Liver metastasis intratumoral
- Liver: hepatic lobules
- Liver: portal area
- Lung adenocarcinoma tumor tissue
- Lung cancer tissue
- Lung parenchymal regions
- Lung tissue
- Lung vascular/perivascular regions
- Lymph
- Lymph node
- Main lymph node
- Melanoma peritumoral tissue
- Melanoma tumor tissue
- Mesenteric lymph node
- Metastasis in distant node
- Metastasis in liver
- Metastasis in lung
- Metastasis in ovary
- N1 regional lymph nodes
- N2 regional lymph nodes
- Non-inflamed colon lamina propria
- Non-inflamed intestinal lamina propria
- Non-lesional dermis
- Non-lesional epidermis
- Non-lesional skin
- Non-regional lymph nodes
- Nontumor liver parenchyma
- NSCLC Intersection of tumor tissue and normal pulmonary tissue
- NSCLC peritumoral tissue
- NSCLC tissue (tumor+stroma)
- NSCLC tumor islets (nests)
- NSCLC tumor stroma
- NSCLC tumor tissue
- NSCLC Tumor tissue homogenate
- Oesophageal adenocarcinoma tumor centre
- Oesophageal adenocarcinoma tumor edge
- Ovarian cancer tumor tissue
- Palatine tonsils
- Pancreatic cancer stroma
- Pancreatic tissue
- Pancreatic tumor tissue
- Pericardial effusion
- Peri-intestinal lymph node
- Peripheral bronchial biopsy specimens
- Peritoneum
- Peritumoral region of tumor-draining/sentinel lymph node - metastatic
- Peyer’s patches
- Plasma
- Plasma arterial
- Plasma from cord blood
- Pleural effusion
- Prostate cancer tissue
- Prostate tissue
- Rectum mucosa
- Renal tissue
- Renal tumor capsula
- Renal tumor margin
- Renal tumor stroma
- Renal tumor tissue
- Right flexure mucosa
- Saliva
- Seeding metastasis
- Serum
- Serum from tumor
- Sigmoid colon lamina propria
- Sigmoid colon mucosa
- Skin
- Small intestine
- Small intestine lamina propria
- Spleen
- Sputum
- Squamous cell carcinoma tumor tissue
- Stroma region of colon
- Suction Blister Fluids
- Synovial fluid
- Synovial membrane
- Synovial membrane intima
- Synovial membrane subintima
- Synovial membrane-around lymphocyte clusters
- Synovial tissue
- Thyroid adenoma tumor tissue
- Thyroid carcinoma tumor tissue
- Thyroid tissue
- Transbronchial (alveolar tissue) biopsies
- Tumor
- Tumor region of colon
- Tumor-draining/sentinel lymph node
- Tumor-draining/sentinel lymph node - metastatic
- Tumor-draining/sentinel lymph node - non-metastatic
- Urine
- Vitreous
519 molecules (cytokines, chemokines, growth factors, other molecules like PGE2, LTE4 etc), press to view details;
- 12-hydroxyeicosatetraenoic acid (12-HETE)
- 15-hydroxyeicosatetraenoic acid (15-HETE)
- 25-hydroxyvitamin D (25(OH)D)
- 5-hydroxyeicosatetraenoic acid (5-HETE)
- 6-Keto-Prostaglandin F1α (6-Keto-PGF1α)
- 8-Hydroxy-2'-deoxyguanosine (8-OHdG)
- 8-isoprostane
- 9a,11b-Prostaglandin F2 (9a,11b-PGF2)
- Abeta42
- Adenosine deaminase (ADA)
- Adiponectin
- Adipsin
- Adrenocorticotropic hormone (ACTH)
- ALA (alpha-linolenic acid)
- Alanine aminotransferase (ALT)
- Albumin
- ALP (Alkaline phosphatase)
- Alpha-1 antitrypsin
- Alpha-1 globulin
- Alpha1-fetoprotein
- Alpha-2 globulin
- Alpha2-antiplasmin (A2PI)
- Alpha2-macroglobulin (a2M)
- Alpha-tocopherol
- Amylase
- Androstenedione
- Angiopoietin-2
- Angiostatin
- anti-EGFR IgG
- anti-HBc
- Anti-SEA IgE (anti-staphylococcus enterotoxin A)
- Anti-SEB IgE (anti-staphylococcus enterotoxin B)
- ApoA-I
- ApoA-II
- ApoA-IV
- ApoB
- ApoC-II [Apolipoprotein C-II]
- ApoC-III
- ApoE
- APRIL
- Arachidonic Acid
- Arginase I
- Ascorbic acid
- Aspartate aminotransferase (AST)
- Axl (tyrosine-protein kinase 7)
- BAFF
- BAMBI
- Bcl-2
- Beta-2-microglobulin
- Betacellulin (BTC)
- Beta-globulin
- b-FGF (basic fibroblast growth factor, FGF2)
- Bilirubin direct
- Bilirubin indirect
- Bilirubin total
- Blood urea nitrogen
- Brain natriuretic peptide (BNP)
- Brain-derived neurotrophic factor (BDNF)
- C1q (Complement component 1q)
- C1s (Complement component 1s)
- C1s inactivator
- C2 (Complement component 2)
- C3 (Complement component 3)
- C3 PA (properdin factor B)
- C3c (Complement component 3c)
- C3d (Complement component 3d)
- C4 (Complement component 4)
- C9 (Complement component 9)
- CA 72-4 (cancer antigen 72-4)
- CA125 (cancer antigen 125)
- CA12-5 (cancer antigen 12-5)
- CA15-3 (cancer antigen 15-3)
- CA19-9 (cancer antigen 19-9)
- Carbamide
- Carcinoembryonic antigen (CEA)
- Cardiac Troponin I (cTnI)
- Carotenoid
- Cathelicidin (LL-37)
- cccDNA
- CCL1 [C-C motif chemokine Ligand 1]
- CCL11
- CCL13
- CCL14a [C-C motif chemokine Ligand 14 alpha]
- CCL15
- CCL16 (HCC-4)
- CCL17
- CCL18
- CCL19
- CCL2
- CCL20
- CCL21
- CCL22
- CCL23
- CCL24
- CCL25
- CCL26
- CCL27
- CCL28
- CCL3
- CCL4
- CCL5 [C-C motif chemokine Ligand 5]
- CCL7
- CCL8
- CCP (Cyclic Citrullinated Peptide) antibodies
- CD200 (OX-2) glycoprotein
- CGRP [Calcitonin Gene Related Protein]
- Chitinase-3-like protein 1 (YKL-40)
- Cholesterol
- Cholesteryl ester
- Cholinesterase (butyrylcholinesterase)
- CITP (carboxy-terminal telopeptide of collagen type I)
- Citrate
- CKMB (creatine kinase isoenzyme)
- Collagen IV (C-IV)
- Complement factor B
- Cortisol
- C-peptide
- C-reactive protein (CRP)
- Creatine kinase
- Creatinine
- CTRP15 (Complement C1q/tumor necrosis factor-related protein 15)
- CTRP6 (C1q/tumor necrosis factor- α-related protein-6)
- CX3CL1
- CXCL1
- CXCL10
- CXCL11
- CXCL12 [C-X-C motif chemokine Ligand 12]
- CXCL12a [C-X-C motif chemokine Ligand 12 alpha]
- CXCL13
- CXCL16
- CXCL2
- CXCL3
- CXCL4
- CXCL5
- CXCL6
- CXCL7
- CXCL9
- CYFRA 21.1
- Cystatin C (CysC)
- Cysteinyl leukotrienes (Cys-LTs)
- Cytokeratin18 (CK18)
- D-dimer (fibrin degradation product)
- DGLA (dihomo-gamma linolenic acid)
- DHA (Docosahexaenoic acid)
- DHEA (dehydroxyepiandrostenedione)
- DNAse1
- DNAse1L3
- DPA (Docosapentaenoic acid)
- ECP [Eosinophil Cationic Protein]
- Elafin
- Elastin-derived peptide
- EMMPRIN (CD147)
- Endoglin (CD105)
- Endotoxin
- Eosinophil protein Х (EPX)
- EPA (Eicosapentaenoic acid)
- Epidermal Growth Factor (EGF)
- ErbB2(CD340, HER-2)
- Estradiol (E2)
- FABP-2
- Fas
- Ferritin
- FGF
- FGF-2 ( fibroblast growth factor 2)
- FGF21
- Fibrin
- Fibrin Degradation Products (FDP)
- Fibrinogen
- FLCs kappa
- FLCs lambda
- Flt3‑L
- Folate
- Folate receptor beta (FR‐beta)
- Follicle-stimulating hormone (FSH)
- Follistatin
- Free Choline
- Free Fatty acids (FFA)
- Free Glycerol
- Free testosterone
- Gamma-globulin
- gamma-Glutamyl Transpeptidase (GGT)
- Gamma-tocopherol
- GCSF [Granulocyte Colony-Stimulating Factor]
- GDF15
- GH (growth hormone/somatotropin)
- GHR (Growth hormone receptor)
- Glial cell-derived neurotrophic factor (GDNF)
- Globulin
- Glucose
- Glutathione peroxidase (GSH-PX)
- Glycoprotein 130 (gp130)
- Glycyl-proline-dipeptidyl aminopeptidase (GPDA)
- GMCSF [Granulocyte-Macrophage Colony-Stimulating Factor]
- Granulysin (GNLY)
- GranzymeA
- GranzymeB
- GRO [Growth-Related Oncogene]
- GSH (reduced glutathione)
- GSSG (oxidised glutathione)
- H2O2
- Haptoglobin
- hBD-2 (human β-defensin 2)
- hBD-3 (human β-defensin 3)
- HBeAg
- HB-EGF (Heparin-binding EGF-like growth factor)
- HBsAg
- HBV DNA
- HBV RNA
- HCV RNA
- HDL-cholesterol
- HDL-unesterified cholesterol
- HE4 (Human epididymis protein 4)
- Hemoglobin
- Hepatocyte growth factor (HGF)
- Hepcidin
- High mobility group box 1 (HMGB1, amphoterin)
- high sensitive troponin I (hsTnI)
- High-sensitivity C-reactive protein (hs-CRP)
- Hippurate
- Histamine
- HIV RNA
- HNPs (human neutrophil peptides, defensins)
- Homocysteine
- Hyaluronic acid (HA)
- ICAM
- ICAM-1
- IFN lambda2 (IL28a)
- IFNa [Interferon alpha]
- IFNa2
- IFNb
- IFNg [Interferon gamma]
- IFNGR1
- IFN-lambda2/3
- IgA
- IgE
- IGF-1 (insulin growth factor 1)
- IGFBP-1
- IGFBP-2 (insulin like growth factor binding protein 2)
- IGFBP-3
- IGFBP-4
- IgG
- IgG1
- IgG2
- IgG3
- IgG4
- IgM
- IL1
- IL10
- IL11
- IL12
- IL12a (IL12p35)
- IL12b (IL23p40)
- IL12p70
- IL13
- IL15
- IL16
- IL17
- IL17a
- IL17af
- IL17F
- IL18
- IL18 BPa
- IL18BP (Interleukin-18 Binding Protein)
- IL19
- IL1a
- IL1b
- IL1RA [Interleukin-1 Receptor Antagonist]
- IL1RAcP
- IL1RL1 [Interleukin 1 Receptor Like 1]
- IL2
- IL20
- IL21
- IL22
- IL23 (p19/p40)
- IL23p19 (IL23a)
- IL24
- IL25
- IL26
- IL27
- IL28a
- IL29
- IL2R
- IL2Ra (sCD25)
- IL3
- IL31
- IL32
- IL33
- IL34
- IL35
- IL36
- IL37
- IL4
- IL-41 (Meteorin-like protein)
- IL5
- IL5 Ralpha
- IL6
- IL7
- IL8
- IL9
- Immune complexes (IC)
- Immunoreactive LTC4 (iLTC4)
- INFa2 [Interferon alpha 2]
- Insulin
- Interferon (IFN)
- Iron
- ischemia-modified albumin (IMA)
- Kallikrein 8
- Keratinocyte growth factor
- KL-6
- Kynurenine
- Lactate
- Lactate dehydrogenase
- Laminin (LN)
- LDL-cholesterol
- Leptin
- LIF (leukemia inhibitory factor)
- LIGHT (TNFSF14, CD258)
- Linoleic Acid
- Lipase
- Lipocalin-2
- Lp(a) (lipoprotein A)
- LRG (leucine-rich alpha-2 glycoprotein)
- LTB4
- LTC4
- LTD4
- LTE4
- Luteinizing hormone (LH)
- Lysozyme
- MAO [Monoamine Oxidase]
- Mast cell chymase
- Mast cell tryptase
- MCP (CD46)
- MCSF
- MDA (malondialdehyde)
- MIF
- MMP1
- MMP10
- MMP12
- MMP13
- MMP2
- MMP3
- MMP7
- MMP8
- MMP9
- M-protein (Myeloma protein)
- MSPa (macrophage stimulating protein a)
- MUFA (Monounsaturated Fatty Acids)
- Myeloperoxidase (MPO)
- Myoglobin
- Neopterin
- Neurofilament light chain
- Neuron-specifc enolase (NSE)
- Neuropeptide Y
- Neutrophil elastase
- NGF [Nerve Growth Factor]
- NGF-beta (beta-nerve growth factor)
- NLRP3 (Nod-like receptor protein 3 inflammasome)
- NO [Nitric Oxide]
- Nonesterified Fatty Acid (NEFA)
- Non-HDL-unesterified cholesterol
- Notch-3
- NT-proBNP (N-terminal brain natriuretic peptide)
- Oleic Acid
- Oncostatin-M
- ONOO (Peroxynitrite)
- Osteocalcin
- Osteopontin (OPN)
- Parathormone (PTH)
- PARC (recombinant human MIP-4)
- PC-III (type III pre-collagen)
- PDGF
- PDGF-BB [Platelet Derived Growth Factor-BB]
- PDGF-АА
- Pentraxin-3
- Perforin
- Periostin
- Peroxiredoxin 4 (Prx4)
- PGE1
- PGE2 [Prostaglandin E2]
- Phosphatidylcholine
- PIIINP (procollagen-III N-terminal peptide)
- PINP (amino-terminal propeptide of procollagen type I)
- PIVKA-II
- Plasmin-alpha2-plasmin inhibitor complex (PIC)
- Plasminogen
- Plasminogen activator inhibitor-1 (PAI-1)
- Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)
- Platelet-Activating Factor (PAF)
- Pleiotrophin (PTN)
- PlGF-1 (Placental growth Factor 1)
- Prealbumin
- Presepsin
- pro-BNP (pro-B-type natriuretic peptide)
- Procalcitonin
- Procollagen-3
- Progastrin‐releasing peptide (ProGRP)
- Prolactin (PRL)
- Prostaglandin D2
- Prostaglandin F2b (PGF2b)
- Prostaglandin F2α (PGF2α)
- Protein carbonyls
- Protein total
- PSA (prostate‐specific antigen)
- P-tau (phosphorylated tau)
- PUFA (Polyunsaturated Fatty Acids)
- RANKL (TNFSF11)
- Resistin
- Retinol-binding protein (RBP)
- RF (Rheumatoid Factor)
- RF-IgM
- RIPK1 (receptor-interacting protein kinase-1)
- sAbetaPPbeta
- sC5b-9
- sCD14
- sCD163
- sCD23
- sCD27
- sCD30
- sCD40L
- SCGF-b (Stem Cell Growth Factor beta)
- sc-kit (SCFR)
- Secretory Leukocyte Protease Inhibitor (SLPI)
- sEGFR (Soluble epidermal growth factor receptor)
- Selenium
- Serum amyloid A
- sE-selectin
- SFA (Saturated Fatty Acids)
- sFasL
- sFRP-3
- Sgp130 (Soluble Glycoprotein 130)
- sIL-18Ra
- sIL1R1 (Soluble Interleukin-1 Receptor-1)
- sIL1R2 (Soluble Interleukin-1 Receptor-2)
- sIL1R3 (Soluble Interleukin-1 Receptor-3)
- sIL1R4 (Soluble Interleukin-1 Receptor-4)
- sIL2R
- sIL2Ra (Soluble Interleukin-2 Receptor subunit alpha)
- sIL6R
- sIL6Ra
- sIL7R
- sILT3
- SLAMF8
- sL-selectin
- Soluble transferrin receptor (sTfR)
- SP-40,40 (clusterin)
- sPD-L1
- Sphingomyelin
- sP-selectin
- Squamous cell carcinoma antigen (SCC)
- sST2 (Soluble suppression of tumorigenicity-2)
- Stem Cell Factor (SCF)
- sTIE-2 (soluble angiopoietin receptor 2)
- sTNF-R1
- sTNF-R2
- sTREM2 (soluble triggering receptor expressed on myeloid cells 2)
- Substance P (SP)
- SuperOxide Dismutase (SOD)
- Surfactant protein A (SP-A)
- Surfactant protein D (SP-D)
- sVEGFR1
- sVEGFR2
- Taurine
- TGFa
- TGFb
- TGFb1
- TGFb1R1
- TGFb1R2
- TGFb2
- TGFb3
- Thioredoxin 1 (TRX1)
- Thrombin-antithrombin complex (TAT)
- Thrombopoietin (TPO, MGDF)
- Thrombospondin-2 (THBS2)
- Thromboxane B2 (TXB2)
- Thyroglobulin (TG)
- Tim-3 (HAVCR2)
- TIMP1
- TIMP2
- Tissue factor
- Tissue Plasminogen Activator (tPA)
- Tissue plasminogen activator (tPA)/plasminogen activator inhibitor type I (PAI) complex (tPA/PAI)
- TL1A (TNFSF15)
- TNFa
- TNFb
- TNFR1
- TNFRSF19L
- TNTHSST (high-sensitivity troponin T)
- Total bile acid (TBA)
- Total cholesterol
- Total testosterone
- TRAIL (TNF-related apoptosis-inducing ligand)
- TRAIL R1
- Transferrin
- Triglyceride
- Triglycerides
- Troponin
- Troponin I
- Troponin T
- Tryptase
- TSLP
- T-tau (total tau)
- TWEAK
- Unesterified cholesterol
- Urate
- Urokinase-type plasminogen activator (uPA)
- VAP-1 (vascular adhesion protein-1)
- VCAM-1 (vascular cell adhesion molecule-1)
- VEGF [Vascular Endothelial Growth Factor]
- VEGF-A
- VEGF-C
- VEGF-D
- VIP [Vasoactive Intestinal Peptide]
- Vitamin A
- Vitamin B12
- Vitamin B6
- VLDL
- XCL1
- α-hydroxybutyrate dehydrogenase (α-HBDH)
- α-L-fucosidase
172 cell types and states, press to view details;
- Activated B-cells
- Activated Eosinophils
- Activated Monocytes
- Activated suppressor T cells
- Activated Tc
- Activated T-cells
- Activated Th1
- Activated switched memory B-cells
- Antigen Presenting Cell (APC)
- Apoptotic cells
- Apoptotic eosinophils
- Atypical memory B-cells
- Basophils
- B-cells
- Blast cells
- Bm1-cells
- Bm2-cells
- Bm3-cells
- Bm4-cells
- Bm5 Early cells
- Bm5 Late cells
- Breg cells
- Cells
- Central memory T-cells
- Circulating endothelial cells
- Circulating endothelial progenitor cells
- Circulating tumor cells (CTCs)
- Columnar epithelial cells
- Dendritic Cells (DC)
- Dermal dendritic cells
- Double positive T cells (DP T cells)
- Double-Negative B-cells
- Double-negative T cells
- Double-Positive (DP) memory Th-cells
- Effector memory B-cells
- Effector memory T-cells
- Effector Tc-cells
- Effector T-cells
- Effector Th-cells
- Eosinophil
- Epidermal cells
- Epithelial cells
- Fibroblast-like synoviocytes
- Follicular Treg cells (Tfr)
- gamma-delta T17-cells
- gamma-delta T-cells
- Germinal Center B-cells
- G-MDSC [Granulocytic Myeloid-Derived Suppressor Cells]
- Hepatocytes
- HFC (high fluorescent cell)
- Histiocytes
- IDEC/IDDC
- Immature B cells
- Immature granulocytes
- Immature T-cells
- Immature transitional B cells
- Immune cells
- Immunocytes(T-cells,B-cells,Mast cells)
- Induced regulatory T cells
- Inflammatory Dendritic Epidermal Cells (IDEC)
- Innate lymphoid cells 2 (CRTH2+)
- Invariant natural killer T-cell
- Kupffer cells
- Langerhans Cells (LC)
- Lymph node-resident Dendritic cell (LNDC)
- Lymphocytes
- Macrophages
- Mast cells
- Mast cells progenitor
- Mature B cells
- Mature Dendritic Cells (DC)
- Mature Langerhans cells
- mDC [Myeloid Dendritic Cells]
- Memory B-cells
- Memory regulatory T-cells
- Memory Tc-cells
- Memory T-cells
- memory Th17.1-cells
- memory Th17-cells
- Memory Th1-cell
- memory Th22-cells
- memory Th2-cells
- memory Th-cells
- Metachromatic cells (mast cells and basophils)
- M-MDSC [Monocytic Myeloid-Derived Suppressor Cells]
- Monocytes
- Monocytes/macrophages
- Mononuclear cells
- Myeloid cells
- Myeloid Dendritic Cells 1 (mDC1)
- Myeloid Dendritic Cells 2 (mDC2)
- Myeloid-Derived Suppressor Cells (MDSC)
- Naive B-cells
- Naive regulatory B-cells
- Naive regulatory T-cells
- Naive suppressor T cells
- Naive Tc-cell
- Naive T-cells
- Naive Th1
- Naive Th-cells
- Natural Effector B-cells
- Natural killer T-cells
- Neutrophil
- Neutrophil total
- Neutrophils Nonsegmented
- Neutrophils Segmented
- NK [Natural Killer cells]
- NK1
- NK17
- NK2
- NKT [Natural Killer-like T-cells]
- Non-memory B cells
- Non‐switched memory B-cells
- nucleated RBCs
- Pan-leukocytes
- PBMC (Lymphocytes and Monocytes)
- PD-L1+ Cell
- Peripheral blood monocytes
- Plasma B-cells
- Plasmablasts
- Plasmacytoid Dendritic Cells (pDC)
- Platelets
- PMN-MDSCs [Mononuclear Myeloid-Derived Suppressor Cell]
- Polymorphonuclear (PMN) leukocytes
- Precursor neutrophils
- Precursor of Germinal Center B-cells
- Red blood cells
- Resting class-switched memory B-cells
- Resting neutrophils
- Reticulocyte
- Sensory Nerve Endings
- Squamous cells
- Stem Cell Memory T cell (Tscm)
- Stromal cells
- Suppressor T cells
- Suppressor T-lymphocytes
- Switch precursor B-cells
- Switched memory B-cells
- Tc17-cell
- Tc1-cell
- Tc22-cell
- Tc2-cell
- Tc9-cell
- Tc-cells
- T-cells
- Tconv cells
- Tcreg-cells
- Teff/Treg cell
- Terminally differentiated effector T cells (EMRA)
- Tfh17-cells
- Tfh1-cells
- Tfh2-cells
- Tfh-cells (follicular helper T-cells)
- Th0-cells
- Th17.1-cells
- Th17-cells
- Th1-cells
- Th22-cells
- Th2-cells
- Th9-cells
- Th-activated
- Th-cells
- Th-cells exhausted
- T-helper lymphocytes
- TIP-DC (TNF and iNOS-producing dendritic cell)
- Total cell count
- Tph-cells (peripheral helper T-cells)
- Transitional B cells
- Transitional memory T-cells
- Treg-cells
- Trm-cells (tissue-resident memory T cells)
- White Blood Cells (WBC)
52169 values of cytokine/cell concentrations;
data extracted from 1420 papers/other public sources.

CYTOCON DB is developed as a web application based on the ASP.NET MVC framework. It works under Microsoft IIS web server. The data warehouse is a Microsoft SQL Server database. The user interface application is implemented using Telerik Kendo UI and Bootstrap.

Versions of the database:

• Commercial version entitled as “CYTOCON DB”

• Public version entitled as “CYTOCON DB Open”

CYTOCON DB

• CYTOCON DB is a version of the database which is accessible via purchasing the commercial license

• To arrange the purchase, please contact us by email: support@insysbio.com

• Both content and functionality of CYTOCON DB is described above and updated on the monthly basis (approximately 1500 cell/molecule concentrations per month)

CYTOCON DB Open version

• CYTOCON DB Open is a version of the database which is accessible for public use

• To access CYTOCON DB Open, please visit www.cytocon-open.insysbio.com

• CYTOCON DB Open has the same functionality as CYTOCON DB

• Content of CYTOCON DB Open is described at www.cytocon-open.insysbio.com

• Both content and functionality of CYTOCON DB Open will be updated once per year

e-mail for correspondence: support@insysbio.com

Cytocon DB

About CYTOCON

355 disease types, press to view details;

210 tissues/physiological fluids, press to view details;

519 molecules (cytokines, chemokines, growth factors, other molecules like PGE2, LTE4 etc), press to view details;

172 cell types and states, press to view details;