About CYTOCON
CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.
CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.
CYTOCON team makes an effort in two directions: the collection and processing of appropriate data on human immune cell and cytokine concentrations available in public domain (content of CYTOCON DB) and the development of tools/methods for processing, extraction and visualization of the data (CYTOCON DB).
Key features of CYTOCON DB:
- Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
- Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
- Search query may include following patient group attributes:
- demographic characteristics (age, race, gender, etc);
- number of patients in the study.
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Search query may take into account disease-specific clinically measured characteristics, for example:
- Asthma: FEV1;
- SLE: SLEADAI range, interferon signature;
- Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
- etc.
- Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
- Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
- Graphic representation of search results: average value, dispersion, source.
- Export of search results in csv format
Content of CYTOCON DB:
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- Airway (bronchial) epithelium
- Airway lamina propria
- Airway smooth muscle
- Basement membrane of epidermis
- Basement membrane of epidermis lesional
- Basement membrane of epidermis nonlesional
- Benign lung lesion homogenates
- Blood
- Blood arterial
- Blood from tumor
- Bone marrow
- Bronchial glands
- Bronchial mucosa
- Bronchial subepithelial tissue
- Bronchial submucosa
- Bronchial tissue
- Bronchial wash
- Bronchoalveolar carcinoma tumor tissue
- Broncho-alveolar lavage (BAL)
- Cerebrospinal fluid (CSF)
- Colon
- Colonic lamina propria
- Coproextracts
- Dermis
- Dermis papillary
- Dermis papillary lesional
- Dermis papillary nonlesional
- Dermis upper
- Dermis upper lesional
- Dermis upper nonlesional
- Endobronchial (airway) biopsies
- Epidermis
- Esophageal tumor tissue lysate
- Exhaled Breath Condensate
- Gastric tissue
- Gastric tumor tissue
- Induced Sputum
- Intratumor soft tissue of synovial sarcoma
- Invasive margin of tumor soft tissue of synovial sarcoma
- Lesional dermis
- Lesional epidermis
- Lesional skin
- Lung adenocarcinoma tumor tissue
- Lung cancer tissue
- Lung tissue
- Lymph
- Lymph node
- Melanoma peritumoral tissue
- Melanoma tumor tissue
- Non-lesional dermis
- Non-lesional epidermis
- Non-lesional skin
- NSCLC peritumoral tissue
- NSCLC tumor islets (nests)
- NSCLC tumor stroma
- NSCLC tumor tissue
- Pericardial effusion
- Peripheral bronchial biopsy specimens
- Peritoneum
- Plasma
- Plasma arterial
- Plasma from cord blood
- Pleural effusion
- Serum
- Serum from tumor
- Skin
- Small intestine
- Sputum
- Squamous cell carcinoma tumor tissue
- Stroma region of colon
- Suction Blister Fluids
- Transbronchial (alveolar tissue) biopsies
- Tumor
- Tumor region of colon
- Urine
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- 14528 values of cytokine/cell concentrations;
- data extracted from 543 papers/other public sources.
CYTOCON DB is developed as a web application based on the ASP.NET MVC framework. It works under Microsoft IIS web server. The data warehouse is a Microsoft SQL Server database. The user interface application is implemented using Telerik Kendo UI and Bootstrap.
Versions of the database:
• Commercial version entitled as “CYTOCON DB”
• Public version entitled as “CYTOCON DB Open”
CYTOCON DB
• CYTOCON DB is a version of the database which is accessible via purchasing the commercial license
• To arrange the purchase, please contact us by email: cytocon@insysbio.com
• Both content and functionality of CYTOCON DB is described above and updated on the monthly basis (approximately 1500 cell/molecule concentrations per month)
CYTOCON DB Open version
• CYTOCON DB Open is a version of the database which is accessible for public use
• To access CYTOCON DB Open, please visit www.cytocon-open.insysbio.com
• CYTOCON DB Open has the same functionality as CYTOCON DB
• Content of CYTOCON DB Open is described at www.cytocon-open.insysbio.com
• Both content and functionality of CYTOCON DB Open will be updated once per year
e-mail for correspondence: cytocon@insysbio.com