About CYTOCON
CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.
CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.
CYTOCON team makes an effort in two directions: the collection and processing of appropriate data on human immune cell and cytokine concentrations available in public domain (content of CYTOCON DB) and the development of tools/methods for processing, extraction and visualization of the data (CYTOCON DB).
Key features of CYTOCON DB:
- Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
- Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
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Search query may include following patient group attributes:
- demographic characteristics (age, race, gender, etc);
- number of patients in the study.
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Search query may take into account disease-specific clinically measured characteristics, for example:
- Asthma: FEV1;
- SLE: SLEADAI 2K range, interferon signature;
- Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
- etc.
- Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
- Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
- Graphic representation of search results: average value, dispersion, source.
- Export of search results in csv format
Content of CYTOCON DB:
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- Airway (bronchial) epithelium
- Airway lamina propria
- Airway smooth muscle
- Benign lung lesion homogenates
- Blood
- Blood arterial
- Bone marrow
- Bronchial glands
- Bronchial mucosa
- Bronchial subepithelial tissue
- Bronchial submucosa
- Bronchial tissue
- Bronchial wash
- Bronchoalveolar carcinoma tumor tissue
- Broncho-alveolar lavage (BAL)
- Colon
- Colonic lamina propria
- Coproextracts
- Endobronchial (airway) biopsies
- Exhaled Breath Condensate
- Induced Sputum
- Intratumor soft tissue of synovial sarcoma
- Invasive margin of tumor soft tissue of synovial sarcoma
- Lesional dermis
- Lesional epidermis
- Lesional skin
- Lung adenocarcinoma tumor tissue
- Lung cancer tissue
- Lung tissue
- Lymph
- Lymph node
- Melanoma tumor tissue
- Non-lesional dermis
- Non-lesional epidermis
- Non-lesional skin
- NSCLC tumor islets (nests)
- NSCLC tumor stroma
- NSCLC tumor tissue
- Peripheral bronchial biopsy specimens
- Plasma
- Plasma arterial
- Pleural effusion
- Serum
- Sputum
- Squamous cell carcinoma tumor tissue
- Stroma region of colon
- Suction Blister Fluids
- Transbronchial (alveolar tissue) biopsies
- Tumor
- Tumor region of colon
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- 6704 values of cytokine/cell concentrations;
- data extracted from 396 papers/other public sources.
CYTOCON DB is developed as a web application based on the ASP.NET MVC framework. It works under Microsoft IIS web server. The data warehouse is a Microsoft SQL Server database. The user interface application is implemented using Telerik Kendo UI and Bootstrap.
e-mail: cytocon@insysbio.com
Demo version of CYTOCON DB.
To access demo version of CYTOCON DB, please visit www.cytocon-demo.insysbio.com.
The access to the full version of CYTOCON DB can be obtained via purchasing the commercial license. To arrange the purchase, please contact us by email: cytocon@insysbio.com
v.1.1.2020.1704