Cytocon DB

About CYTOCON


CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.

CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.

CYTOCON team makes an effort in two directions: the collection and processing of appropriate data on human immune cell and cytokine concentrations available in public domain (content of CYTOCON DB) and the development of tools/methods for processing, extraction and visualization of the data (CYTOCON DB).


Key features of CYTOCON DB:

  •  Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
  • Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
  •  Search query may include following patient group attributes:
    • demographic characteristics (age, race, gender, etc);
    • number of patients in the study.
  • Search query may take into account disease-specific clinically measured characteristics, for example:
    • Asthma: FEV1;
    • SLE: SLEADAI 2K range, interferon signature;
    • Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
    • etc.
  • Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
  • Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
  • Graphic representation of search results: average value, dispersion, source.
  • Export of search results in csv format

Content of CYTOCON DB:

    • Acute allergic reactions
    • Adenocarcinoma of bronchus or lung
    • Adult T-cell leukemia/lymphoma
    • Adult T-cell leukemia/lymphoma patients with dermatophytosis
    • Allergic asthma
    • Allergic rhinitis
    • Alveolar rhabdomyosarcoma
    • Alveolar soft part sarcoma
    • Angiosarcoma
    • Asthma
    • Asthma, food allergy and atopic dermatitis
    • Atopic allergy
    • Atopic asthma
    • Atopic dermatitis
    • Atopy, nonasthma
    • Bacterial pneumonia
    • B-cell non-Hodgkin lymphoma (B-NHL)
    • Benign lung lesions
    • Benign soft-tissue neoplasm
    • Bronchial asthma
    • Bronchiectasis
    • Bronchoalveolar carcinoma
    • Bullous pemphigoid
    • Carcinoma
    • Chondrosarcoma
    • Chordoma
    • Chronic bronchitis (COPD)
    • Chronic cough
    • Chronic idiopathic urticaria, hives
    • Chronic kidney disease
    • Chronic obstructive pulmonary disease (COPD)
    • Chronic Spontaneous Urticaria
    • Clear cell sarcoma
    • Colitis
    • Colitis associated cancer (CAC)
    • Contact dermatitis
    • Crohn's disease
    • Cutaneous Lupus Erythematosus
    • Cutaneous T-cell lymphoma
    • Dedifferentiated liposarcoma
    • Dermatomyositis
    • Dermatophytosis
    • Desmoplastic small round cell tumour
    • DFSP dermatofibrosarcoma protuberans
    • Discoid Lupus Erythematosus
    • Dysbacteriosis
    • Embryonal rhabdomyosarcoma
    • End stage renal disease
    • Eosinophilia
    • Eosinophilic asthma
    • Eosinophilic bronchitis
    • Epithelioid sarcoma
    • Esophageal carcinoma
    • Ewing sarcoma
    • Familial lecithin:cholesterol acyltransferase (LCAT) deficiency
    • Familial lipoprotein lipase (LPL) deficiency
    • Food allergy and atopic dermatitis
    • GIST gastrointestinal stromal tumor
    • Healthy control
    • Hypertrophic Scar
    • Infections
    • Inflammatory Bowel Diseases
    • Irritable Bowel Syndrome
    • Large cell carcinoma of bronchus or lung
    • Leiomyosarcoma
    • Low-grade fibromyxoid sarcoma
    • Lung cancer
    • Melanoma
    • MPNST malignant peripheral nerve sheath tumor
    • Myasthenia gravis
    • Myxofibrosarcoma
    • Myxoid/round cell liposarcoma (MRCL)
    • Neutrophilic asthma
    • Nocturnal Asthma
    • Non-Hodgkin Lymphoma
    • Non-Small Cell Lung Cancer (NSCLC)
    • Non-squamous bronchial carcinoma
    • Non-translocation sarcoma
    • Obesity
    • Osteosarcoma
    • Paucigranulocytic asthma
    • Pemphigus vulgaris
    • Primary bronchial carcinoma
    • Psoriasis
    • Refractory Bone and Soft Tissue Sarcoma
    • Renal carcinoma
    • Rheumatoid arthritis
    • Sarcoidosis
    • Sarcoma
    • Sclerodermia
    • Seborrheic dermatitis
    • Septic shock
    • Small cell carcinoma of bronchus or lung
    • Soft tissue sarcoma
    • Solid malignant tumors
    • Solitary fibrous tumor
    • Sporadic colorectal cancer (CRC)
    • Squamous cell carcinoma of bronchus or lung
    • Stat3-Hyper-IgE syndrome
    • Synovial sarcoma
    • System indolent mastocytosis
    • Systemic lupus erythematosus
    • Translocation-associated sarcoma
    • Tuberculosis
    • Ulcerative colitis
    • UPS undifferentiated pleomorphic sarcoma
    • Wegener’s granuloma
    • Well-differentiated liposarcoma
    • Airway (bronchial) epithelium
    • Airway lamina propria
    • Airway smooth muscle
    • Benign lung lesion homogenates
    • Blood
    • Blood arterial
    • Bone marrow
    • Bronchial glands
    • Bronchial mucosa
    • Bronchial subepithelial tissue
    • Bronchial submucosa
    • Bronchial tissue
    • Bronchial wash
    • Bronchoalveolar carcinoma tumor tissue
    • Broncho-alveolar lavage (BAL)
    • Colon
    • Colonic lamina propria
    • Coproextracts
    • Endobronchial (airway) biopsies
    • Exhaled Breath Condensate
    • Induced Sputum
    • Intratumor soft tissue of synovial sarcoma
    • Invasive margin of tumor soft tissue of synovial sarcoma
    • Lesional dermis
    • Lesional epidermis
    • Lesional skin
    • Lung adenocarcinoma tumor tissue
    • Lung cancer tissue
    • Lung tissue
    • Lymph
    • Lymph node
    • Melanoma tumor tissue
    • Non-lesional dermis
    • Non-lesional epidermis
    • Non-lesional skin
    • NSCLC tumor islets (nests)
    • NSCLC tumor stroma
    • NSCLC tumor tissue
    • Peripheral bronchial biopsy specimens
    • Plasma
    • Plasma arterial
    • Pleural effusion
    • Serum
    • Sputum
    • Squamous cell carcinoma tumor tissue
    • Stroma region of colon
    • Suction Blister Fluids
    • Transbronchial (alveolar tissue) biopsies
    • Tumor
    • Tumor region of colon
    • 12-hydroxyeicosatetraenoic acid (12-HETE)
    • 15-hydroxyeicosatetraenoic acid (15-HETE)
    • 5-hydroxyeicosatetraenoic acid (5-HETE)
    • 6-Keto-Prostaglandin F1α (6-Keto-PGF1α)
    • 8-isoprostane
    • 9a,11b-Prostaglandin F2 (9a,11b-PGF2)
    • Adiponectin
    • Adipsin
    • ALA (alpha-linolenic acid)
    • Albumin
    • Alpha-1 antitrypsin
    • Anti-SEA IgE (anti-staphylococcus enterotoxin A)
    • Anti-SEB IgE (anti-staphylococcus enterotoxin B)
    • ApoA-I
    • ApoA-II
    • ApoA-IV
    • ApoB
    • ApoC-III
    • ApoE
    • APRIL
    • Arachidonic Acid
    • BAFF
    • b-FGF (basic fibroblast growth factor)
    • C1q (Complement component 1q)
    • C1s (Complement component 1s)
    • C1s inactivator
    • C2 (Complement component 2)
    • C3 PA (properdin factor B)
    • C3c (Complement component 3c)
    • C3d (Complement component 3d)
    • C4 (Complement component 4)
    • C9 (Complement component 9)
    • Carcinoembryonic antigen (CEA)
    • CCL1
    • CCL11
    • CCL17
    • CCL18
    • CCL19
    • CCL2
    • CCL20
    • CCL21
    • CCL22
    • CCL23
    • CCL24
    • CCL25
    • CCL26
    • CCL27
    • CCL3
    • CCL4
    • CCL5
    • CCL7
    • CCL8
    • CCP (Cyclic Citrullinated Peptide antibody)
    • CGRP (Calcitonin gene-regulated protein)
    • Chitinase-3 like 1
    • Cholesteryl ester
    • Complement factor B
    • C-reactive protein
    • Creatinine
    • CX3CL1
    • CXCL1
    • CXCL10
    • CXCL11
    • CXCL12
    • CXCL13
    • CXCL5
    • CXCL6
    • CXCL9
    • Cysteinyl leukotrienes (Cys-LTs)
    • DGLA (dihomo-gamma linolenic acid)
    • DHA (Docosahexaenoic acid)
    • DPA (Docosapentaenoic acid)
    • Elastin-derived peptide
    • Endotoxin
    • Eosinophil Cationic Protein
    • EPA (Eicosapentaenoic acid)
    • Epidermal Growth Factor (EGF)
    • Ferritin
    • FGF
    • FGF-2 ( fibroblast growth factor 2)
    • Fibrinogen
    • Free Choline
    • Free Glycerol
    • GCSF (Granulocyte colony-stimulating factor)
    • Globulin
    • Glycoprotein 130 (gp130)
    • GMCSF
    • GranzymeB
    • Growth-related oncogene
    • GSH (reduced glutathione)
    • GSSG (oxidised glutathione)
    • H2O2
    • hBD-2 (human β-defensin 2)
    • hBD-3 (human β-defensin 3)
    • HDL-cholesterol
    • HDL-unesterified cholesterol
    • Hemoglobin
    • Hepatocyte growth factor
    • High mobility group box 1 (HMGB1, amphoterin)
    • Histamine
    • I-309
    • ICAM
    • IFNa
    • IFNA2
    • IFNb
    • IFNg
    • IgA
    • IgE
    • IGFBP-3
    • IgG
    • IgG1
    • IgG2
    • IgG3
    • IgG4
    • IgM
    • IL10
    • IL11
    • IL12
    • IL12b
    • IL12p70
    • IL13
    • IL15
    • IL16
    • IL17
    • IL17a
    • IL17af
    • IL17F
    • IL18
    • IL19
    • IL1a
    • IL1b
    • IL1RA ( interleukin-1 receptor antagonist)
    • IL2
    • IL20
    • IL21
    • IL22
    • IL23
    • IL24
    • IL25
    • IL26
    • IL27
    • IL28a
    • IL29
    • IL3
    • IL31
    • IL32
    • IL33
    • IL34
    • IL35
    • IL36
    • IL37
    • IL4
    • IL5
    • IL6
    • IL7
    • IL8
    • IL9
    • Immune complexes (IC)
    • Immunoreactive LTC4 (iLTC4)
    • Keratinocyte growth factor
    • LDL-cholesterol
    • Leptin
    • LIGHT (TNFSF14, CD258)
    • Linoleic Acid
    • Lipocalin-2
    • LTB4
    • LTC4
    • LTD4
    • LTE4
    • Lysozyme
    • Mast cell chymase
    • Mast cell tryptase
    • MCSF
    • MDA (malondialdehyde)
    • MIF
    • MMP1
    • MMP10
    • MMP12
    • MMP2
    • MMP8
    • MMP9
    • MUFA (Monounsaturated Fatty Acids)
    • Nerve Growth Factor
    • Neuropeptide Y
    • Neutrophil elastase
    • NO
    • Non-HDL-unesterified cholesterol
    • Oleic Acid
    • Oncostatin-M
    • ONOO (Peroxynitrite)
    • Osteocalcin
    • PDGF-АА
    • Pentraxin-3
    • Perforin
    • Periostin
    • PGE1
    • PGE2
    • Phosphatidylcholine
    • Plasminogen activator inhibitor-1
    • Platelet-activating factor (PAF)
    • Prostaglandin D2
    • Prostaglandin F2b (PGF2b)
    • Prostaglandin F2α (PGF2α)
    • Protein carbonyls
    • Protein total
    • PUFA (Polyunsaturated Fatty Acids)
    • Resistin
    • RF (Rheumatoid Factor)
    • sCD163
    • sCD23
    • sCD27
    • sCD30
    • sCD40L
    • Selenium
    • SFA (Saturated Fatty Acids)
    • Sgp130 (Soluble Glycoprotein 130)
    • sIL2R
    • sIL2Ra
    • sIL6R
    • sILT3
    • SOD (superoxide dismutase)
    • Sphingomyelin
    • sST2 (Soluble suppression of tumorigenicity-2)
    • Stem Cell Factor (SCF)
    • sTNF-R1
    • sTNF-R2
    • Substance P
    • Surfactant protein (SP-A)
    • sVEGFR2
    • TGFa
    • TGFb
    • TGFb1
    • TGFb2
    • TGFb3
    • Thioredoxin 1 (TRX1)
    • Thromboxane B2 (TXB2)
    • TIMP1
    • TIMP2
    • Tissue factor
    • TNFa
    • TNFb
    • Total cholesterol
    • Triglyceride
    • Tryptase
    • TSLP
    • TWEAK
    • Unesterified cholesterol
    • Urea nitrogen
    • Vasoactive Intestinal Peptide
    • VEGF
    • VEGFC
    • Activated B-cells
    • Activated eosinophils
    • Activated Tc
    • Activated Th1
    • Apoptotic cells
    • Apoptotic eosinophils
    • Basophils
    • B-cells
    • Bm1
    • Bm2
    • Bm3
    • Bm4
    • Bm5 Early
    • Bm5 Late
    • Cells
    • Central memory T-cells
    • Columnar epithelial cells
    • Dendritic cell
    • Dermal dendritic cells
    • Double-negative B cells (IgD-, CD27-)
    • Effector memory T-cells
    • Effector T-cells
    • Eosinophil
    • Epithelial cell
    • Follicular B cells (CD23+)
    • Full polarized macrophages of 1 type (CD32+)
    • Full polarized macrophages of 2 type (CD163+)
    • Germinal Center B-cells
    • Histiocytes
    • Immature B cells
    • Immunocytes(T-cells,B-cells,Mast cells)
    • Inflammatory dendritic epidermal cells
    • Innate lymphoid cells 2 (CRTH2+)
    • Invariant natural killer T-cell
    • Keratinocytes
    • Langerhans Cells
    • Lymphocytes
    • Macrophages
    • Mast cells
    • Mast cells progenitor (CD34+)
    • Mature dendritic cells
    • Memory B-cells
    • Memory regulatory T-cells
    • Memory Tc-cells
    • Memory T-cells
    • Memory Th1-cell
    • Metachromatic cells (mast cells and basophils)
    • Monocytes
    • Monocytes/macrophages
    • Monocytic MDSCs (MO-MDSCs)
    • Mononuclear cells
    • Myeloid cells
    • Myeloid-derived suppressor cells
    • Naive B-cells
    • Naive regulatory T-cells
    • Naive Tc-cell
    • Naive T-cells
    • Naive Th1
    • Natural Effector B-cells (CD27+,IgM+,IgD+)
    • Natural killer cell
    • Neutrophil
    • Neutrophils Nonsegmented
    • Neutrophils Segmented
    • NK1
    • NK17
    • NK2
    • Non-memory B cells
    • Non‐switched memory/ marginal zone like B-cells
    • PD-L1+ Cell
    • Peripheral blood monocytes
    • Peripheral blood mononuclear MDSCs (PMN-MDSCs)
    • Plasma B-cells
    • Plasmablasts
    • Plasmacytoid dendritic cell
    • Platelets
    • Precursor neutrophils
    • Precursor of Germinal Center B-cells
    • Red blood cells
    • Resting neutrophils
    • Sensory Nerve Endings
    • Squamous cells
    • Switched memory B-cells
    • Tc0-cells (CD8+)
    • Tc17-cell
    • Tc1-cell
    • Tc22-cell
    • Tc2-cell
    • Tc9-cell
    • Tc-cells
    • T-cells
    • Th0-cells
    • Th17-cells
    • Th1-cells
    • Th22-cells
    • Th2-cells
    • Th9-cells
    • Th-cells
    • Total cell count
    • Transitional B cells
    • Treg(Foxp3+)
    • Treg-cells
    • White blood cells
  • 6704 values of cytokine/cell concentrations;
  • data extracted from 396 papers/other public sources.

CYTOCON DB is developed as a web application based on the ASP.NET MVC framework. It works under Microsoft IIS web server. The data warehouse is a Microsoft SQL Server database. The user interface application is implemented using Telerik Kendo UI and Bootstrap.

e-mail: cytocon@insysbio.com

 

Demo version of CYTOCON DB.

To access demo version of CYTOCON DB, please visit www.cytocon-demo.insysbio.com.

The access to the full version of CYTOCON DB can be obtained via purchasing the commercial license. To arrange the purchase, please contact us by email: cytocon@insysbio.com

v.1.1.2020.1704