openapi: 3.0.3
info:
  title: CYTOCON API
  description: |
    This API allows access to **CYTOCON DB** (**C**ell and c**YTO**kine**CON**centrations **D**ata**B**ase), 
    a manually curated online database containing baseline of cells and cytokines concentrations in different tissues of 
    both healthy individuals and patients suffering from various pathologies.
    **Important!** In order to make a query, all parameters must be chosen from the database dictionaries.
  termsOfService: https://cytocon-open.insysbio.com/TermOfUse
  contact:
    email: support@insysbio.com
  license:
    name: Apache 2.0
    url: http://www.apache.org/licenses/LICENSE-2.0.html
  version: 1.0.0
externalDocs:
  description: Find out more about CYTOCON
  url: https://cytocon.insysbio.com/Index.aspx
servers:
  - url: https://cytocon.insysbio.com/api/v1
tags:
  - name: diseases
    description: List of disease names
  - name: tissues_types
    description: Tissues types
  - name: species
    description: Species types
  - name: markers
    description: Cells markers
  - name: patient_group_attributes
    description: Patient groups attributes
  - name: disease_attributes
    description: Disease attributes
  - name: query_data
    description: Query result data 

paths:
  /diseases:
    get:
      tags:
        - diseases
      summary: |
        Return full list of the diseases to be used in Query (optional parameter for query).
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/Disease'          
           
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB. 
      security:
        - cytocon_auth:
            - read:diseases
  /tissues_types:
    get:
      tags:
        - tissues_types
      summary: |
        Return list of tissue types (compartments where cells or molecules measured) to be used in Query (optional parameter for query).
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/TissueType'          
            
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB.
      security:
        - cytocon_auth:
            - read:tissues_types
  /species:
    get:
      tags:
        - species
      summary: |
        Return list of Species (names for cells and molecules) to be used in Query
         (mandatory parameter for query).
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/Species'          
            
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB.
      security:
        - cytocon_auth:
            - read:species
  /markers:
    get:
      tags:
        - markers
      summary: |
        Return list of Markers to be used in Query (optional parameter for query). 
        Users can refine searches for cell concentrations by specifying cell markers 
        (e.g. CD4+ and IL4+ for T-helper type 2 cells).
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/Marker'          
            
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB.
      security:
        - cytocon_auth:
            - read:marker
  /patient_group_attributes:
    get:
      tags:
        - patient_group_attributes
      summary: |
        Return list of patient group attributes. Required for query result output. 
        The results of queries may include demographic information such as age, race, gender,
        and other details, such as the number of patients in the study, if the source provides such information.
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/PatientGroupAttribute'          
            
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB.
      security:
        - cytocon_auth:
            - read:patient_group_attributes
  /disease_attributes:
    get:
      tags:
        - disease_attributes
      summary: |
        Return list of Disease attributes. Required for query result output. 
        The results of queries may include disease-specific clinical measures, 
        e.g. Forced Expiratory Volume (FEV1) for Asthma; SLEDAI 2K range, interferon signature 
        for Systemic Lupus Erythematosus (SLE); SCORAD range, severity, IgE concentration range for Atopic Dermatitis.
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/DiseaseAttribute'          
            
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB.
      security:
        - cytocon_auth:
            - read:disease_attributes
  /query_data:
    get:
      parameters:
      - name: species
        in: query
        description: 'list of species names separated by "," choosed species list. "OR" logical operator'
        required: true
        schema:
          type: string
      - name: tissue_types
        in: query
        description: 'list of tissues names separated by "," choosed tissue_types list. "OR" logical operator'
        schema:
          type: string
      - name: diseases
        in: query
        description: 'list of diseases names separated by "," choosed query list. "OR" logical operator'
        schema:
          type: string
      - name: markers
        in: query
        description: 'list of markers names separated by "," choosed markers list. "OR" logical operator'
        schema:
          type: string
      tags:
        - query_data
      summary: |
        Return list with query output according to parameters provided.
        There are a total of four parameters, where "Species" is mandatory, and "Tissue types", "Diseases",
        and "Cell markers" are optional. Multiple inputs can be selected for all parameters, but currently,
        only the "OR" logic is supported.
      responses:
        '200':
          description: successful operation
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/QueryData'          
            
        '400':
          description: Invalid status value. This response appears when the required object does not exist in the DB.
      security:
        - cytocon_auth:
            - read:query_data

components:
  schemas:
    Disease:
      required:
        - name
        - id
      type: object
      properties:
        id:
          type: integer
          format: int64
          example: 10
        name:
          type: string
          example: Asthma
          description: Disease name available
      
    TissueType:
      required:
        - name
        - id
      type: object
      properties:
        id:
          type: integer
          format: int64
          example: 10
        name:
          type: string
          description: Tissue name available
          example: Lymph node
     
    Species:
      required:
        - name
        - id
      type: object
      properties:
        id:
          type: integer
          format: int64
          example: 10
        name:
          type: string
          description: Species name available
          example: T-cells
      
    Marker:
      required:
        - name
        - id
      type: object
      properties:
        id:
          type: integer
          format: int64
          example: 10
        name:
          type: string
          description: Cells marker available
          example: CD4+
      
    PatientGroupAttribute:
      required:
        - name
        - id
      type: object
      properties:
        id:
          type: integer
          format: int64
          example: 10
        name:
          type: string
          description: Patient group name used
          example: Patient number
      
    DiseaseAttribute:
      required:
        - name
        - id
      type: object
      properties:
        id:
          type: integer
          format: int64
          example: 10
        name:
          type: string
          description: Disease attribute name used
          example: Cancer stage (I-IV)
     
    QueryData:
      required:
        - s_name
        - s_val
        - u_base
      type: object
      properties:
        s_name:
          type: string
          description: Species name (Cell or molecule names)
          example: T-cells
        s_unf_val:
          type: string
          description: Species value arithmetic mean (Concentration in unified form of avarage in database. Dimension in pM or k cell/L)
          example: 1498528
        s_disp_unf:
          type: string
          description: Species standard deviation (Unified form of dispersion in database. Dimension in pM or k cell/L)
          example: 190396
        markers:
          type: string
          description: Cell markers (List of markers associated with cells)
          example: CD3+
        s_val:
          type: string
          description: Species value (Concentration in unified units. Dimension in pM or k cell/L)
          example:   1498528
        s_val_isf:
          type: string
          description: Species value in ISF (Concentration in unified units (pM or kcell/L) recalculated regarded interstitial fluid volume)
          example: NA
        s_disp_left:
          type: string
          description: Species dispersion left (Left border in unified units. Dimension in pM or k cell/L)
          example: 60208
        s_disp_right:
          type: string
          description: Species dispersion right (Right border in unified units. Dimension in pM or k cell/L)
          example: NA
        s_disp_min:
          type: string
          description: Species min value (Minimum value in unified units. Dimension in pM or k cell/L)
          example: NA
        s_disp_max:
          type: string
          description: Species max value (Maximum value in unified units. Dimension in pM or k cell/L)
          example: NA
        s_val_org:
          type: string
          description: Species value (original). Original value from source
          example: 67.2
        s_disp_left_org:
          type: string
          description: Species dispersion left(original). Original value from source
          example:   2.7
        s_disp_right_org:
          type: string
          description: Species dispersion right(original). Original value from source
          example: NA
        s_disp_min_org:
          type: string
          description: Species min value(original). Original value from source
          example: NA
        s_disp_max_org:
          type: string
          description: Species max value(original). Original value from source
          example: NA
        u_base:
          type: string
          description: Unified units (pM or kcell/L)
          example: kcells/L
        u_org:
          type: string
          description: Original unit (unit from source)
          example: '%__Lymphocytes_Blood_Atopic dermatitis'
        u_rcl_ass:
          type: string
          description: Recalculation assumptions. If we recalculate the original value (e.g. due to a misprint in the paper or when we need calculate exact number from % using external data), we explicitly explain how and why the recalculation was performed
          example: Exact number calculated from % using averaged concentration of the maternal cell in the tissue and the disease from CYTOCON DB data
        tissue_t:
          type: string
          description: Tissue type
          example: Blood
        disease:
          type: string
          description: Disease
          example: Atopic dermatitis
        avg_t:
          type: string
          description: Average type
          example: Mean
        disp_t:
          type: string
          description: Dispersion type
          example: SEM
        exp_m:
          type: string
          description: Experimental method
          example: FACS (Fluorescence-activated cell sorting)
        id_type:
          type: string
          description: ID type (ID for original source (e.g. PMID))
          example: PMID
        id_val:
          type: string
          description: ID value
          example: 15932386
        link:
          type: string
          description: Link to place in paper where value was found
          example: Table 2, p.949
        source:
          type: string
          description: Source type (e.g paper, book, etc.)
          example: Article
        pg_desc:
          type: string
          description: Patient group description
          example:   All patients suffered from an acute exacerbation of their AD and were treated with pimecrolimus cream 1% twice daily for 3 weeks
        pg_sg:
          type: string
          description: Patient group is subgroup. If a value is extracted in addition to the overall value from a large cohort (e.g., the paper presents data for all patients, then divides it by males and females), we indicate this
          example: No
        has_misprint:
          type: string
          description: If we detect a misprint (e.g., incorrect dimensions), we indicate it
          example: No
        sv_desc:
          type: string
          description: Species values description (additional information that can be useful for users about this value)
          example: NA

        pgAttr1:
          type: string
          description: 'race/ethnicity or group of races of patients'
        pgAttr2:
          type: string
          description: 'number of males in patient group'
        pgAttr3:
          type: string
          description: 'number of females in patient group'
        pgAttr4:
          type: string
          description: 'Average age of the patient group'
        pgAttr10:
          type: string
          description: 'any other attributes of patient group'
        pgAttr11:
          type: string
          description: 'Patient number in the group'
        pgAttr15:
          type: string
          description: 'Patient weight in kg'
        pgAttr16:
          type: string
          description: 'Patient BMI (body mass index) in kg/m2'
        pgAttr17:
          type: string
          description: 'Patient group average height'
        pgAttr18:
          type: string
          description: 'Patient Smoking status'
        pgAttr21:
          type: string
          description: 'Fasting before blood draw (hours)'
        pgAttr22:
          type: string
          description: 'Exclusion criteria for patient group'
        pgAttr23:
          type: string
          description: 'Inclusion criteria for patients'
        pgAttr24:
          type: string
          description: 'Information about treatment'
        pgAttr25:
          type: string
          description: 'additional diagnoses'
        pgAttr26:
          type: string
          description: 'Samples number of the patient group'
        pgAttr27:
          type: string
          description: 'Patient drinking history'
        pgAttr28:
          type: string
          description: 'Alcohol history'
        pgAttr29:
          type: string
          description: 'Waist-Hip Ratio (WHR)'
        pgAttr30:
          type: string
          description: 'Erythrocyte sedimentation rate'
        pgAttr31:
          type: string
          description: 'blood groups'
        pgAttr32:
          type: string
          description: 'Waist circumference i.e. for patients with diabet'

        dsAttr1:
          type: string
          description: 'SCORing Atopic Dermatitis'
        dsAttr4:
          type: string
          description: 'Severity of the disease'
        dsAttr7:
          type: string
          description: 'Atopic dermatitis type'
        dsAttr8:
          type: string
          description: 'Atopic dermatitis phase'
        dsAttr14:
          type: string
          description: 'Forced expiratory volume in 1 second, spirometry characteristic'
        dsAttr15:
          type: string
          description: 'Global initiative for chronic Obstructive Lung Disease (GOLD) criteria'
        dsAttr16:
          type: string
          description: 'High/Low level of IFN1 gene expression'
        dsAttr17:
          type: string
          description: 'SLEDAI 2K score'
        dsAttr18:
          type: string
          description: 'Glucocorticosteroids dose'
        dsAttr19:
          type: string
          description: 'Glucocorticosteroids dose'
        dsAttr20:
          type: string
          description: 'Immunoglobulin E specific concentration'
        dsAttr21:
          type: string
          description: 'Immunoglobulin E total concentration'
        dsAttr25:
          type: string
          description: 'Active/inactive stage of the disease'
        dsAttr26:
          type: string
          description: 'Cancer stage (I-IV)'
        dsAttr27:
          type: string
          description: 'T stage of cancer (TNM)'
        dsAttr28:
          type: string
          description: 'N stage of cancer (TNM)'
        dsAttr29:
          type: string
          description: 'M stage of cancer (TNM)'
        dsAttr30:
          type: string
          description: 'peak expiratory flow'
        dsAttr31:
          type: string
          description: 'fraction of exhaled NO'
        dsAttr33:
          type: string
          description: 'Number of patients using prescribed ICS regularly and properly'
        dsAttr34:
          type: string
          description: 'Daily dose of ICS'
        dsAttr35:
          type: string
          description: 'airway resistance'
        dsAttr36:
          type: string
          description: 'Crohn’s Disease Activity Index (CDAI)'
        dsAttr37:
          type: string
          description: 'Disease duration'
        dsAttr55:
          type: string
          description: 'objective SCORAD'
        dsAttr56:
          type: string
          description: 'TEWL g/m2/h'
        dsAttr57:
          type: string
          description: 'Pruritus score'
        dsAttr58:
          type: string
          description: 'Sleep loss'
        dsAttr59:
          type: string
          description: 'Extent (%) - affected Body Surface Area (BSA)'
        dsAttr60:
          type: string
          description: 'CDLQI - Children’s Dermatology Life Quality Index'
        dsAttr61:
          type: string
          description: 'SH (Skin Hydration) measured on Corneometer CM 825'
        dsAttr62:
          type: string
          description: 'FEV1 % of the patient divided by the average FEV1% in the population for any person of similar age, sex, and body composition'
        dsAttr63:
          type: string
          description: '% reversibility of asthma'
        dsAttr64:
          type: string
          description: 'Provocation concentration (PC) that results in a 20% fall in the forced expiratory volume in 1 second (FEV1)'
        dsAttr65:
          type: string
          description: 'The provocative dose of methacholine causing a ≥20% fall in FEV1 (PD20)'
        dsAttr66:
          type: string
          description: 'Wheal diameter induced by allergen (mm)'
        dsAttr67:
          type: string
          description: 'Status asthmaticus existence'
        dsAttr68:
          type: string
          description: 'FEV1 before salbutamol (% predicted)'
        dsAttr69:
          type: string
          description: 'FEV1 after salbutamol (% predicted)'
        dsAttr70:
          type: string
          description: 'Astma severity score'
        dsAttr71:
          type: string
          description: 'for PMID 24800011'
        dsAttr72:
          type: string
          description: 'Psoriasis Area Severity Index'
        dsAttr73:
          type: string
          description: 'System developed and validated by the EULAR to measure the progress and improvement of Rheumatoid Arthritis'
        dsAttr74:
          type: string
          description: 'Severity score for acute allergic reactions'
        dsAttr75:
          type: string
          description: 'Cancer stage for mixed groups'
        dsAttr76:
          type: string
          description: 'Tumor histological grade'
        dsAttr77:
          type: string
          description: 'Sarcoidosis stages (chest radiograph stages (Scadding criteria))'
        dsAttr78:
          type: string
          description: 'Performance status (Eastern Cooperative Oncology Group)'
        dsAttr79:
          type: string
          description: 'Harvey–Bradshaw Index'
        dsAttr80:
          type: string
          description: 'Endoscopic activity score (Rutgeerts)'
        dsAttr81:
          type: string
          description: 'Clinical activity index (Mayo)'
        dsAttr82:
          type: string
          description: 'Endoscopic activity score (Mayo)'
        dsAttr83:
          type: string
          description: 'Clark''s level is a staging system, which describes the level of anatomical invasion of the melanoma in the skin'
        dsAttr84:
          type: string
          description: 'Systemic Lupus Erythematosus Disease Activity Index'
        dsAttr85:
          type: string
          description: 'Systemic Lupus International Collaborating Clinics/ACR Damage Index; SDI'
        dsAttr86:
          type: string
          description: 'Anti-dsDNA: anti-double-stranded DNA'
        dsAttr87:
          type: string
          description: 'Mini Mental State Examination (MMSE) score'
        dsAttr88:
          type: string
          description: 'SLE disease activity score [ECLAM]'
        dsAttr89:
          type: string
          description: 'APOE E4 carrier or non-carrier (% of patients))'
        dsAttr90:
          type: string
          description: 'ISN/RPS (International Society of Nephrology/Renal Pathology Society) class'
        dsAttr91:
          type: string
          description: 'chronicity index (CI)'
        dsAttr92:
          type: string
          description: 'Expanded Disability Status score'
        dsAttr93:
          type: string
          description: 'W.H.O. grade of cancer'
        dsAttr94:
          type: string
          description: 'Systemic Lupus Activity Measure (SLAM)'
        dsAttr95:
          type: string
          description: 'compensated and decompensated phases'
        dsAttr96:
          type: string
          description: 'Histological activity index for hepatitis'
        dsAttr97:
          type: string
          description: 'Period of infection disease'
        dsAttr98:
          type: string
          description: 'Fibrosis stage for hepatitis B'
        dsAttr99:
          type: string
          description: 'Inflammation grade for chronic hepatitis B'
        dsAttr100:
          type: string
          description: 'for chronic hepatitis B'
        dsAttr101:
          type: string
          description: 'for chronic hepatitis B'
        dsAttr102:
          type: string
          description: 'Anti-dsDNA/reference anti-dsDNA ratio'
        dsAttr103:
          type: string
          description: 'Necroinflammation grading for CHB'
        dsAttr104:
          type: string
          description: 'Hepatitis B e antigen seropositivity'
        dsAttr105:
          type: string
          description: 'hepatitis B core antigen Expression Patterns in Hepatocyte'
        dsAttr106:
          type: string
          description: 'HBsAg Expression Patterns in Hepatocyte'
        dsAttr107:
          type: string
          description: 'For hepatitis'
        dsAttr108:
          type: string
          description: 'HBsAg seropositivity'
        dsAttr109:
          type: string
          description: 'Glomerulonephritis class I-V'
        dsAttr110:
          type: string
          description: 'For Lupus nephritis was added'
        dsAttr111:
          type: string
          description: 'For IgA nephropathy'
        dsAttr112:
          type: string
          description: 'parenchymal liver disease (PLD) score'
        dsAttr113:
          type: string
          description: 'a system for assessing the prognosis of chronic liver disease, primarily cirrhosis'
        dsAttr114:
          type: string
          description: 'Clinical dementia rating (CDR)'
        dsAttr115:
          type: string
          description: 'Activity of inflammation for chronic hepatitis B'
        dsAttr116:
          type: string
          description: 'Hepatitis C Virus genotype'
        dsAttr117:
          type: string
          description: 'Hepatitis B Virus genotype'
        dsAttr118:
          type: string
          description: 'International Federation of Gynecology and Obstetrics clinical stage for uteric cervical cancer'
        dsAttr119:
          type: string
          description: 'Tumor differentiation status'
        dsAttr120:
          type: string
          description: 'Lymph node metastasis existence'
        dsAttr121:
          type: string
          description: 'For Uterine cervical cancer'
        dsAttr122:
          type: string
          description: 'Cancer vasoinvasion existence'
        dsAttr124:
          type: string
          description: 'Human papillomavirus positive/negative'
        dsAttr125:
          type: string
          description: 'Larsen grade value'
        dsAttr126:
          type: string
          description: 'anti-CCP antibody in plasma'
        dsAttr127:
          type: string
          description: 'Anti-HBe antigen in serum for chronic hepatitis B'
        dsAttr128:
          type: string
          description: 'for chronic hepatitis C, HCV-DNA in blood'
        dsAttr129:
          type: string
          description: 'for Rheumatoid arthritis'
        dsAttr130:
          type: string
          description: 'Kellgren-Lawrence grading scale'
        dsAttr131:
          type: string
          description: 'for Rheumatoid arthritis according to DAS28'
        dsAttr132:
          type: string
          description: 'Rheumatoid factor (RF) seropositivity'
        dsAttr133:
          type: string
          description: 'for Rheumatoid arthritis'
        dsAttr134:
          type: string
          description: 'Percent of Non-survivors (i.e. for COVID-19)'
        dsAttr135:
          type: string
          description: 'For Ulderative colitis according to Lichtiger'
        dsAttr136:
          type: string
          description: 'Marburg cancer stage or SCLC'
        dsAttr137:
          type: string
          description: 'For Crohn''s disease'
        dsAttr138:
          type: string
          description: 'Crohn’s Disease Endoscopic Index of Severity (CDEIS)'
        dsAttr139:
          type: string
          description: 'Oral lichen planus type'
        dsAttr140:
          type: string
          description: 'Tumor histology type'
        dsAttr141:
          type: string
          description: 'Her2 expression i.e. for breast cancer'
        dsAttr142:
          type: string
          description: 'Lymphovascular space invasion existence i.e. for Cervical cancer'
        dsAttr143:
          type: string
          description: 'for colorectal cancer'
        dsAttr144:
          type: string
          description: 'Progesteron receptor expression on tumor cells (for breast cancer)'
        dsAttr145:
          type: string
          description: 'Estrogen receptor status for breast cancer'
        dsAttr146:
          type: string
          description: 'Simple Endoscopy Severity'
        dsAttr147:
          type: string
          description: 'Global Initiative for Asthma (GINA)'
        dsAttr148:
          type: string
          description: 'recommended by GINA'
        dsAttr149:
          type: string
          description: 'the tendency to produce an exaggerated IgE immune response to otherwise harmless substances in the environment'
        dsAttr150:
          type: string
          description: 'Harvey-Bradshaw Index'
        dsAttr151:
          type: string
          description: 'Endoscopic severity (Mayo)'
        dsAttr152:
          type: string
          description: 'Positive and Negative Syndrome Scale (PANSS) for schizophrenia'
        dsAttr153:
          type: string
          description: 'severity of depressive symptoms'
        dsAttr154:
          type: string
          description: 'Acute Physiology and Chronic Health Evaluation'
        dsAttr155:
          type: string
          description: 'for HCC'
        dsAttr156:
          type: string
          description: 'Distant metastasis existence, i.e. extrahepatic metastasis for HCC'
        dsAttr157:
          type: string
          description: 'for arthritis'
        dsAttr158:
          type: string
          description: 'Antinuclear antibody (ANA)-seropositivity i.e. for arthritis'
        dsAttr159:
          type: string
          description: 'HLA-B27 seropositivity i.e. for arthritis'
        dsAttr160:
          type: string
          description: 'American Society of Reproductive Medicine (ASRM) classification of endometriosis'
        dsAttr161:
          type: string
          description: 'Phase of the menstrual cycle'
        dsAttr162:
          type: string
          description: 'For prostate cancer'
        dsAttr163:
          type: string
          description: 'The Behcet’s Disease Current Activity Form (BDCAF) transformed index'
        dsAttr164:
          type: string
          description: 'PSI, pneumonia severity index'
        dsAttr165:
          type: string
          description: 'SOFA, Sepsis-related organ failure assessment score'
        dsAttr166:
          type: string
          description: 'SAPS, simplified acute physiology score'
        dsAttr167:
          type: string
          description: 'For Lymphoma'
        dsAttr168:
          type: string
          description: 'For Lymphoma'
        dsAttr169:
          type: string
          description: 'For Lymphoma'
        dsAttr170:
          type: string
          description: 'PCDAI = pediatric Crohn''s disease activity index'
        dsAttr171:
          type: string
          description: 'PUCAI = pediatric ulcerative colitis activity index'
        dsAttr172:
          type: string
          description: 'For Hodgkin''s Lymphoma'
        dsAttr173:
          type: string
          description: 'For Lymphoma'
        dsAttr174:
          type: string
          description: 'For Lymphoma'
        dsAttr175:
          type: string
          description: 'Clinical outcome of the disease'
        dsAttr176:
          type: string
          description: 'For diabets, glycated hemoglobin'
        dsAttr177:
          type: string
          description: 'for COVID-19'
        dsAttr178:
          type: string
          description: 'for IBD'
        dsAttr179:
          type: string
          description: 'For UC'
        dsAttr180:
          type: string
          description: 'for UC'
        dsAttr181:
          type: string
          description: 'Simple endoscopic score for CD'
        dsAttr182:
          type: string
          description: 'For CD'
        dsAttr183:
          type: string
          description: 'for NSCLC'
        dsAttr184:
          type: string
          description: 'for disease severity PMID32979941,p.e3'
        dsAttr185:
          type: string
          description: 'Tumor size (cm)'
        dsAttr186:
          type: string
          description: 'Tumor Infiltrating Lymphocytes PD-L1 expression (for breast cancer)'
        dsAttr187:
          type: string
          description: 'Tumor cell PD-L1 expression (for breast cancer)'
        dsAttr188:
          type: string
          description: 'For AML, French-American-British (FAB) classification system is based on morphology to define specific immunotypes'
        dsAttr189:
          type: string
          description: 'St Gallen 2015 International Expert Consensus for Breast cancer'
        dsAttr190:
          type: string
          description: 'DASO (Days after symptom onset)'
        dsAttr191:
          type: string
          description: 'for COVID-19'
        dsAttr192:
          type: string
          description: 'Breslow thickness is the measurement of the depth of the melanoma from the surface of your skin down through to the deepest poin'
        dsAttr193:
          type: string
          description: 'for COVID-19'
        dsAttr194:
          type: string
          description: 'for MDS'
        dsAttr195:
          type: string
          description: 'Hamilton depression rating scale, without suicide ideation item'
        dsAttr196:
          type: string
          description: 'Buss Perry aggression questionnaire'
        dsAttr197:
          type: string
          description: 'for COVID-19'
        dsAttr198:
          type: string
          description: 'qSOFA, quick Sequential Organ Failure Assessment'
        dsAttr199:
          type: string
          description: 'CMI, Charlson Comorbidity Index'
        dsAttr200:
          type: string
          description: 'anti-HBs seropositivity'
        dsAttr201:
          type: string
          description: 'Model for end-stage liver disease (MELD) scores'
        dsAttr202:
          type: string
          description: 'HBc-antibody seropositivity'
        dsAttr203:
          type: string
          description: 'for COVID-19'
        dsAttr204:
          type: string
          description: 'for Multiple sclerosis and others'
        dsAttr205:
          type: string
          description: 'for Multiple sclerosis'
        dsAttr206:
          type: string
          description: 'Aneurysmal diameter'
        dsAttr207:
          type: string
          description: 'for aneurysma'
        dsAttr208:
          type: string
          description: 'for strokes'
        dsAttr209:
          type: string
          description: 'a cumulative and weighted index used to assess disease  activity across 24 different disease descriptors in patients with SLE'
        dsAttr210:
          type: string
          description: 'measures the overall response to treatment as assessed by the physician'
        dsAttr211:
          type: string
          description: 'for COVID-19'
        dsAttr212:
          type: string
          description: 'for Multiple myeloma'
        dsAttr213:
          type: string
          description: 'for Multiple myeloma'
        dsAttr214:
          type: string
          description: 'ECOG Eastern Cooperative Oncology Group'
        dsAttr215:
          type: string
          description: 'alpha smooth muscle actin - for Pancreatic cancer'
        dsAttr216:
          type: string
          description: 'For Pancreatic cancer'
        dsAttr217:
          type: string
          description: 'HCV-Ab seropositivity'
        dsAttr218:
          type: string
          description: 'for HCC'
        dsAttr219:
          type: string
          description: 'BCLC stage, the Barcelona Clinic Liver Cancer stage'
        dsAttr220:
          type: string
          description: 'a method for assessing β-cell function and insulin resistance (IR) from basal (fasting) glucose and insulin or C-peptide concent'
        dsAttr221:
          type: string
          description: 'for HCC'
        dsAttr222:
          type: string
          description: 'bleeding scale '
        dsAttr223:
          type: string
          description: 'for HCC'
        dsAttr224:
          type: string
          description: 'estimating the risk of short-term mortality from actual clinical data in the first day after admission'
        dsAttr225:
          type: string
          description: 'Bone Lesion Score'
        dsAttr226:
          type: string
          description: '(positive/negative)'
        dsAttr227:
          type: string
          description: 'for Gastric cancer'
        dsAttr228:
          type: string
          description: 'for Crohn Disease'
        dsAttr229:
          type: string
          description: 'for Crohn disease'
        dsAttr230:
          type: string
          description: 'for Crohn Disease'
        dsAttr231:
          type: string
          description: 'Stage 1: Infection ; Stage 2: Asymptomatic ; Stage 3: Symptomatic ; Stage 4: AIDS/Progression of HIV to AIDS.'
        dsAttr232:
          type: string
          description: 'Forced Ventilatory Capacity'
        dsAttr233:
          type: string
          description: 'Total Lung Capacity'
        dsAttr234:
          type: string
          description: 'Diffusion capacity of the Lung for Carbon monoxide corrected for hemoglobin level'
        dsAttr235:
          type: string
          description: 'Disease Activity Score 28 joints combined with CRP value'
        dsAttr236:
          type: string
          description: 'for Multiple sclerosis - an MS relapse, flare-up, or exacerbation'
        dsAttr237:
          type: string
          description: 'for coeliac disease'
        dsAttr238:
          type: string
          description: 'for Coeliac disease'
        dsAttr239:
          type: string
          description: 'Kirsten rat sarcoma viral oncogene homologue (KRAS) is the best-known oncogene'
        dsAttr240:
          type: string
          description: 'EGFR mutation'
        dsAttr241:
          type: string
          description: 'Tumor location'
        dsAttr242:
          type: string
          description: 'Marsh Classification of histologic findings in celiac disease (Oberhuber)'
        dsAttr243:
          type: string
          description: 'For RA and PsA'
        dsAttr244:
          type: string
          description: 'For RA and PsA'
        dsAttr245:
          type: string
          description: 'Larsen score for RA (0–4)'
        dsAttr246:
          type: string
          description: 'Radiological score of sacroileitis for PsA (0–4)'
        dsAttr247:
          type: string
          description: 'BASDAI Bath Ankylosing Spondylitis Disease Activity Index'
        dsAttr248:
          type: string
          description: 'MASES Maastricht Ankylosing Spondylitis Enthesitis Score'
        dsAttr249:
          type: string
          description: 'For COPD'
        dsAttr250:
          type: string
          description: 'MSSS (multiple sclerosis severity score)'
        dsAttr251:
          type: string
          description: 'TJC68'
        dsAttr252:
          type: string
          description: 'SJC66'
        dsAttr253:
          type: string
          description: 'MRss, modified Rodnan skin score'
        dsAttr254:
          type: string
          description: 'the sum of the size of the largest tumor in cm and the total number of tumors in the absence of tumor microvascular invasion.'
        dsAttr255:
          type: string
          description: 'the small number of cancer cells in the body after cancer treatment. An MRD positive test result means that disease was still de'
        dsAttr256:
          type: string
          description: 'Multiple Sclerosis Impact Scale 29'
        dsAttr257:
          type: string
          description: 'Multiple Sclerosis Impact Scale 29,'
        dsAttr258:
          type: string
          description: 'Symbol Digit Modalities Test'
        dsAttr259:
          type: string
          description: 'Ophthalmopathy'
        dsAttr260:
          type: string
          description: 'degree of goiter'
        dsAttr261:
          type: string
          description: 'for Graves disease'
        dsAttr262:
          type: string
          description: 'I (0–1 point), II (2–3  points), and III (4–6 points)'
        dsAttr263:
          type: string
          description: 'For arthritits'
        dsAttr264:
          type: string
          description: 'for IgG4-related disease'
        dsAttr265:
          type: string
          description: 'for IgG4-Related disease'
        dsAttr266:
          type: string
          description: 'ELF score (enhanced liver fibrosis)'
        dsAttr267:
          type: string
          description: 'Disease Activity Score-28 for Rheumatoid Arthritis with ESR'
        dsAttr268:
          type: string
          description: 'Ankylosing Spondylitis Disease Activity Score'
        dsAttr269:
          type: string
          description: 'BASFI functional index'
        dsAttr270:
          type: string
          description: 'BASMI measurement index'
        dsAttr271:
          type: string
          description: 'For RA - CDAI'
        dsAttr272:
          type: string
          description: 'The Dermatology life Quality Index (DLQI) is a ten-question questionnaire used to measure the impact of skin disease on the qual'
        dsAttr273:
          type: string
          description: 'The Nail Psoriasis Severity Index (NAPSI) is a numeric, reproducible, objective, simple tool for evaluation of nail psoriasis.'
        dsAttr274:
          type: string
          description: 'health assessment questionnaire–disability index'
        dsAttr275:
          type: string
          description: 'Anti-Smith Antibody Positivity'
        dsAttr276:
          type: string
          description: ' SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus'
        dsAttr277:
          type: string
          description: 'For ITP'
        dsAttr278:
          type: string
          description: 'For ITP'
        dsAttr279:
          type: string
          description: 'AECA: anti-endothelial cell antibodies'
        dsAttr280:
          type: string
          description: 'Checklist Individual Strength'
        dsAttr281:
          type: string
          description: 'Checklist Individual Strength'
        dsAttr282:
          type: string
          description: 'Checklist Individual Strength'
        dsAttr283:
          type: string
          description: 'Checklist Individual Strength'
        dsAttr284:
          type: string
          description: 'IgG index'
        dsAttr285:
          type: string
          description: 'aspartate aminotransferase–to-platelet ratio index'
        dsAttr286:
          type: string
          description: 'FIB-4, fibrosis index'
        dsAttr287:
          type: string
          description: 'water channel protein aquaporin-4 (AQP4)'
        dsAttr288:
          type: string
          description: 'Ranson score for patients with Acute Pancreatitis'
        dsAttr289:
          type: string
          description: 'Balthazar score (for acute pancreatitis)'
        dsAttr290:
          type: string
          description: 'MCTSI Modified Computed Tomography Severity Index'
        dsAttr291:
          type: string
          description: 'bedside index of severity in acute pancreatitis'
        dsAttr292:
          type: string
          description: 'Glasgow severity score'
        dsAttr293:
          type: string
          description: 'degree of disability/dependence after a stroke'
        dsAttr294:
          type: string
          description: 'International Autoimmune Hepatitis Group'
        dsAttr295:
          type: string
          description: 'Bullous Pemphigoid Disease Area Index score'
        dsAttr296:
          type: string
          description: 'BP180-NC16A'
        dsAttr297:
          type: string
          description: 'BP230-CF'
        dsAttr298:
          type: string
          description: 'BPDAI skin activity score'
        dsAttr299:
          type: string
          description: 'Blisters/erosions score'
        dsAttr300:
          type: string
          description: 'Erythema/urticaria score'
        dsAttr301:
          type: string
          description: 'for Bullous pemphigoid'
        dsAttr302:
          type: string
          description: 'ESSDAI EULAR Sjögren Disease Activity Index'
        dsAttr303:
          type: string
          description: 'ESSPRI EULAR Sjögren Patient Reported Index'
        dsAttr304:
          type: string
          description: 'MEDS, mortality in emergency department sepsis'
        dsAttr305:
          type: string
          description: 'ASA, American Society of Anesthesiologists physical status'
        dsAttr306:
          type: string
          description: 'MS(±): fulfilled/not fulfilled IDF (International Diabetes Foundation) criteria for metabolic syndrome'
        dsAttr307:
          type: string
          description: 'SDAI Simple Disease Activity Index'
        dsAttr308:
          type: string
          description: 'VAS-PAIN (0-100mm)'
        dsAttr309:
          type: string
          description: 'For PsA'
        dsAttr310:
          type: string
          description: 'BODE Index'
        dsAttr311:
          type: string
          description: 'SPARCC Spondyloarthritis Research Consortium of Canada Enthesitis Index'
        dsAttr312:
          type: string
          description: 'SJC swollen joint count'
        dsAttr313:
          type: string
          description: 'FEV1/FVC'
        dsAttr314:
          type: string
          description: 'eczema area and severity index'
        dsAttr315:
          type: string
          description: 'investigator’s global assessment'
        dsAttr316:
          type: string
          description: 'visual analogue scale'
        dsAttr317:
          type: string
          description: 'Visual analogur score'
        dsAttr318:
          type: string
          description: 'Forced Ventilatory Capacity (L)'
        dsAttr319:
          type: string
          description: 'BBB impairment'
        dsAttr322:
          type: string
          description: 'positive or negative group'
        dsAttr323:
          type: string
          description: 'Mexican version of the Systemic Lupus Erythematosus Disease Activity Index'
        dsAttr324:
          type: string
          description: 'Systemic Lupus International Collaborating Clinics'
        dsAttr325:
          type: string
          description: 'anti-nuclear antibody'
        dsAttr326:
          type: string
          description: 'Anti-Ro/SSA titre for SLE'
        dsAttr327:
          type: string
          description: 'Anti-La/SSB antibodies'
        dsAttr328:
          type: string
          description: 'anti-Smith antibodies'
        dsAttr329:
          type: string
          description: 'maximal mid-expiratory flow'
        dsAttr330:
          type: string
          description: 'Cytoplasmic anti-neutrophil cytoplasmic antibodies'
        dsAttr331:
          type: string
          description: 'Perinuclear anti-neutrophil cytoplasmic antibodies'
        dsAttr332:
          type: string
          description: 'Anticardiolipin antibody'
        dsAttr333:
          type: string
          description: 'British Isles Lupus Assessment Group'
        dsAttr334:
          type: string
          description: 'antinucleosome antibodies'
        dsAttr335:
          type: string
          description: 'anti-U1 small nuclear ribonucleoprotein'
        dsAttr336:
          type: string
          description: 'antinuclear ribonucleoprotein'
        dsAttr337:
          type: string
          description: 'anti-Sjögren’s syndromerelated (SS) antigen A'
        dsAttr338:
          type: string
          description: 'anti-Sjögren’s syndromerelated (SS) antigen B'
        dsAttr339:
          type: string
          description: 'The 5-item Asthma Control Questionnaire'
        dsAttr340:
          type: string
          description: 'a patient-reported measure of asthma-specific health-related quality of life'
        dsAttr341:
          type: string
          description: 'AM asthma symptom score'
        dsAttr342:
          type: string
          description: 'PM asthma symptom score'
        dsAttr343:
          type: string
          description: 'Charlson Index'
        dsAttr344:
          type: string
          description: 'Elixhauser Index'
        dsAttr345:
          type: string
          description: 'FEV1 reversibility'
        dsAttr346:
          type: string
          description: 'Asthma Control Questionnaire'
        dsAttr347:
          type: string
          description: 'For asthma'
        dsAttr348:
          type: string
          description: 'For asthma'
        dsAttr349:
          type: string
          description: 'ACQ, asthma control questionnaire'
        dsAttr350:
          type: string
          description: 'HADS‐D: depressive symptoms of the Hospital Anxiety and Depression Scale;'
        dsAttr351:
          type: string
          description: 'HADS‐A: anxiety symptoms of the Hospital Anxiety and Depression Scale'
        dsAttr352:
          type: string
          description: 'Modified Borg Scale scores'
        dsAttr353:
          type: string
          description: 'for text data'
        dsAttr354:
          type: string
          description: 'FEF: Forced expiratory flow'
        dsAttr355:
          type: string
          description: 'FEF: Forced expiratory flow'
        dsAttr356:
          type: string
          description: 'The National Institutes of Health Stroke Scale'
        dsAttr357:
          type: string
          description: 'Hamilton Depression Rating Scale'
        dsAttr358:
          type: string
          description: 'Hamilton Anxiety Rating Scale'
        dsAttr360:
          type: string
          description: 'modified British Medical Research Council'
        dsAttr361:
          type: string
          description: 'CAT (COPD assessment test) score'
        dsAttr362:
          type: string
          description: 'Acute Physiology and Chronic Health Evaluation'
        dsAttr363:
          type: string
          description: 'simplified acute physiology score'
        dsAttr364:
          type: string
          description: 'Response Evaluation Criteria in Solid Tumors'
        dsAttr365:
          type: string
          description: 'For Chronic hepatitis C'
        dsAttr366:
          type: string
          description: 'STAI: State-Trait Anxiety Inventory'
        dsAttr367:
          type: string
          description: 'STAI: State-Trait Anxiety Inventory'
        dsAttr368:
          type: string
          description: 'Diabetes Quality of Life'
        dsAttr369:
          type: string
          description: 'For rhinitis'
        dsAttr370:
          type: string
          description: 'Dietary Approaches to Stop Hypertension (range: 0–9, with higher scores indicating better DASH concordance);'
        dsAttr371:
          type: string
          description: 'for asthma'
        dsAttr372:
          type: string
          description: 'RAI (Ritchie’s articular index)'
        dsAttr373:
          type: string
          description: 'SF-MPQ (simplified McGill pain questionnaire)'
        dsAttr374:
          type: string
          description: 'six-point composite disease activity index using erythrocyte sedimentation rate (ESR)'
        dsAttr375:
          type: string
          description: 'six-point composite disease activity index using Creactive protein (CRP)'
        dsAttr376:
          type: string
          description: 'TJC, tender joint count'
        dsAttr377:
          type: string
          description: 'Epstein-Barr virus (EBV)'
        dsAttr378:
          type: string
          description: '0-Dead, 100-Normal'
        dsAttr379:
          type: string
          description: 'disease activity index'
        dsAttr380:
          type: string
          description: 'disease severity scale for systemic sclerosis'
        dsAttr381:
          type: string
          description: 'Juvenile Arthritis Disease Activity Score'
        dsAttr382:
          type: string
          description: 'JSpaDA score'
        dsAttr383:
          type: string
          description: 'sJADAS10score'
        dsAttr384:
          type: string
          description: 'State Trait Anxiety Inventory'
        dsAttr385:
          type: string
          description: 'Active joint count'
        dsAttr386:
          type: string
          description: 'Limited joint count'
        dsAttr387:
          type: string
          description: 'Depressive symptoms (MFQ-C)'
        dsAttr388:
          type: string
          description: 'Juvenile Arthritis Disease Activity Score'
        dsAttr389:
          type: string
          description: 'Childhood Health Assessment Questionnaire'
        dsAttr390:
          type: string
          description: 'Physician global assessment VAS (0–10 cm)'
        dsAttr391:
          type: string
          description: 'Patient general VAS'
        dsAttr392:
          type: string
          description: 'CHAQ disability index'
        dsAttr393:
          type: string
          description: 'CHAQ pain visual analogue score'
        dsAttr394:
          type: string
          description: 'myositis specific autoantibody'
        dsAttr395:
          type: string
          description: 'Modified Systemic Manifestation Score'
        dsAttr396:
          type: string
          description: 'physical function'
        dsAttr397:
          type: string
          description: 'physicians assessment of activity'
        dsAttr398:
          type: string
          description: 'health-related quality of life'
        dsAttr399:
          type: string
          description: 'patients well-being'
        dsAttr400:
          type: string
          description: '71-joint count Juvenile Arthritis Disease Activity Score'
        dsAttr401:
          type: string
          description: 'health assessment questionnaire'
        dsAttr402:
          type: string
          description: 'PGA-A, Physician global assessment of activity'
        dsAttr403:
          type: string
          description: 'PGA-D, Physician Global Assessment of Damage'
        dsAttr404:
          type: string
          description: 'mLoSSI, modified Localized Scleroderma Skin Score'
        dsAttr405:
          type: string
          description: 'LoSDI, Localized Scleroderma Damage Index'
        dsAttr406:
          type: string
          description: 'anti-ssDNA, anti-single stranded DNA antibodies'
        dsAttr407:
          type: string
          description: 'AHA, anti-histone antibodies'
        dsAttr408:
          type: string
          description: 'Patient-GA, patient Global Assessment of disease impact'
        dsAttr409:
          type: string
          description: 'Parent-GA, parent Global Assessment of disease impact'
        dsAttr410:
          type: string
          description: 'CMAS, Childhood Myositis Assessment Scale'
        dsAttr411:
          type: string
          description: 'DAS total'
        dsAttr412:
          type: string
          description: 'DAS muscle'
        dsAttr413:
          type: string
          description: 'DAS skin'
        dsAttr414:
          type: string
          description: 'MSA antibodies (Myositis-specific antibodies)'
        dsAttr415:
          type: string
          description: 'Manual muscle testing of 8 muscle groups'
        dsAttr416:
          type: string
          description: 'SMA motor score (HMFSE, 0-66) (Hammersmith Functional Motor Scale-Expanded)'
        dsAttr417:
          type: string
          description: 'on tumor cells'
        dsAttr418:
          type: string
          description: 'seropositivity for SARS-CoV-2 IgG antibodies'
        dsAttr419:
          type: string
          description: 'viral load'
        dsAttr420:
          type: string
          description: 'Anti-centromere antibodies in serum'
        dsAttr421:
          type: string
          description: 'Anti-Scl-70 antibodies in serum'
        dsAttr422:
          type: string
          description: 'viral load i CSF'
        dsAttr423:
          type: string
          description: 'Anti-Ro52 antibodies seropositivity'
        dsAttr424:
          type: string
          description: 'anti-Ribonucleoprotein'
        dsAttr425:
          type: string
          description: 'Anti-Phospholipids i.e. for Lupus nephritis'
        dsAttr426:
          type: string
          description: 'WHO Class i.e. for Lupus nephritis'
        dsAttr427:
          type: string
          description: 'Non-renal SLEDAI i.e. for Lupus nephritis'
        dsAttr428:
          type: string
          description: 'anti Acetylcholine receptor in sera'
        dsAttr429:
          type: string
          description: 'AchR Acetylcholine receptor in sera titer'
        dsAttr430:
          type: string
          description: 'Myasthenia Gravis Foundation of America'
        dsAttr431:
          type: string
          description: 'for Myastenia gravis'
        dsAttr432:
          type: string
          description: 'high-avidity antinuclear antibody (ANA) of the IgG isotype'
        dsAttr433:
          type: string
          description: 'Autoimmune Bullous Skin Disorder Intensity Score'
        dsAttr434:
          type: string
          description: 'Anti-Desmoglein1 antibody'
        dsAttr435:
          type: string
          description: 'anti-Desmoglein3 AB'
        dsAttr436:
          type: string
          description: 'FSS: Fatigue Severity Scale'
        dsAttr437:
          type: string
          description: 'SpO2: oxygen saturation'
        dsAttr438:
          type: string
          description: 'HLA-B51 positivity'
        dsAttr439:
          type: string
          description: 'Myasthenia Gravis Activities of Daily Living'
        dsAttr440:
          type: string
          description: 'For MDS'
        dsAttr441:
          type: string
          description: 'WPSS: WHO classification-based Prognostic Scoring System'
        dsAttr442:
          type: string
          description: 'the total amount of iron in your blood plus the UIBC (Unsaturated iron-binding capacity)'
        dsAttr443:
          type: string
          description: 'TSAT = transferrin saturation'
        dsAttr444:
          type: string
          description: 'IPSS-R (Revised International Prognostic Scoring System)'
        dsAttr445:
          type: string
          description: 'IPSS (International Prognostic Scoring System)'
        dsAttr446:
          type: string
          description: 'Unsaturated Iron Binding Capacity'
        dsAttr447:
          type: string
          description: 'Homeostasis model assessment of insulin resistance'
        dsAttr448:
          type: string
          description: 'Homeostasis model assessment of insulin resistance'
        dsAttr449:
          type: string
          description: 'Homeostasis model assessment of insulin resistance'
        dsAttr450:
          type: string
          description: 'key features of acromegaly: signs and symptoms (S), associated comorbidities (A), GH levels (G), IGF-1 levels (I), and the Tumor'
        dsAttr451:
          type: string
          description: 'Lung RV in liters'
        dsAttr452:
          type: string
          description: 'Lung residual volume (%)'
        dsAttr453:
          type: string
          description: ' The five-point Fleischner grading system offers the possibility to more precisely grade the visual severity of parenchymal emph'

      xml:
        name: query_data    
  securitySchemes:
    cytocon_auth:
      type: oauth2
      flows:
        implicit:
          authorizationUrl: https://cytocon.insysbio.com/oauth/token
          scopes:
            read:diseases: read diseases
            read:tissues_types: read tissue types
            read:species: read species
            read:markers: read markers
            read:patient_group_attributes: read patient group attributes
            read:disease_attributes: read disease attributes
            read:query_data: read query data
    api_key:
      type: apiKey
      name: Authorization
      in: header